SZM-1209

Name: SZM-1209
Brand: TargetMol
SKU: T73382
Rating: 4.5 (1 reviews)

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Catalog No. T73382Cas No. 2919801-86-6

SZM-1209 is a potent and specific RIPK1 inhibitor with oral activity, displaying a dissociation constant (Kd) of 85 nM. It demonstrates substantial anti-necroptotic efficacy with an EC50 of 22.4 ± 8.1 nM and possesses therapeutic effects against systemic inflammatory response syndrome (SIRS) and acute lung injury (ALI) [1].

SZM-1209

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Catalog No. T73382Cas No. 2919801-86-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$279	35 days	35 days
5 mg	$1,090	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	SZM-1209 is a potent and specific RIPK1 inhibitor with oral activity, displaying a dissociation constant (Kd) of 85 nM. It demonstrates substantial anti-necroptotic efficacy with an EC50 of 22.4 ± 8.1 nM and possesses therapeutic effects against systemic inflammatory response syndrome (SIRS) and acute lung injury (ALI) [1].
Targets&IC50	RIPK1:85 nM (Kd), RIPK3:>10000 nM (Kd)
In vitro	SZM-1209 blocks necroptotic cell death in a dose-dependent manner [1]. Specifically, SZM-1209 (0-1 μM, 6 h) inhibits the phosphorylation of the necroptosis signaling pathway involving RIPK1, RIPK3, and MLKL [1].
In vivo	SZM-1209 administered at doses ranging from 25 to 100 mg/kg through oral gavage (灌胃) significantly counteracts inflammation in a systemic inflammatory response syndrome (SIRS) model induced by mTNF-α, reversing mortality in mice [1]. Additionally, when injected intraperitoneally (腹腔注射) at the same dosage, SZM-1209 markedly alleviates acute lung injury (ALI) by reducing pulmonary edema and pathological damage [1].

Chemical Properties

Molecular Weight	696.71
Formula	C₃₁H₂₉F₅N₄O₅S₂
Cas No.	2919801-86-6
Smiles	#N/A

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc