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Balofloxacin
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Catalog No. T0116Cas No. 127294-70-6
Balofloxacin, a quinolone antibiotic, can inhibit the synthesis of bacterial DNA by interfering with the DNA gyrase.
Balofloxacin
Copy Product Info🥰Excellent
Purity: 99.98%
Catalog No. T0116Cas No. 127294-70-6
Balofloxacin, a quinolone antibiotic, can inhibit the synthesis of bacterial DNA by interfering with the DNA gyrase.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 mg | $44 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.98%
Appearance:Solid
Color:White
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Product Introduction
Balofloxacin AI Summary
Balofloxacin exhibits a broad spectrum of bioactivity, including potent antimycobacterial properties with MIC values of 0.78 µg/mL against Mycobacterium phlei and 0.39 µg/mL against Mycobacterium smegmatis. It also shows activity against Mycobacterium tuberculosis with MIC values of 16.0 µg/mL for strain 09710 and 8.0 µg/mL for strain H37Rv. In addition, it has demonstrated antitubercular activity with an IC50 value of 0.5 µg/mL and exhibits cytotoxicity against African green monkey Vero cells (CC50 = 317,000 nM).
The compound is active against various strains of Staphylococcus aureus, including methicillin-resistant and drug-resistant strains, with moderate MIC values. It also shows antibacterial activity against Escherichia coli, though at slightly higher MIC values. Balofloxacin exhibits moderate hepatotoxicity, reflected by a 28.6% increase in liver toxicity based on clinical-chemistry results; however, acute liver toxicity was not observed.
Moreover, Balofloxacin shows promising antiviral activity, including inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at 10 µM concentrations and mixed inhibition profiles against the SARS-CoV-2 3CL-Pro protease. It also inhibited SARS-CoV-2 in HRCE cells, though the activity did not meet the hit criteria. Additionally, it shows bioactivity against the Ebola virus and as a delayed death inhibitor of the malarial parasite plastid with nanomolar potency.
The lipophilicity of Balofloxacin is characterized by a LogP value of -1.11, and it also acts as a moderate HDAC6 inhibitor with up to 14.42% inhibition in enzymatic assays. Lastly, it exhibits bioactivity in Schwann cell luciferase assays at micromolar potency levels..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Balofloxacin, a quinolone antibiotic, can inhibit the synthesis of bacterial DNA by interfering with the DNA gyrase. |
| Molecular Weight | 389.42 |
| Formula | C20H24FN3O4 |
| Cas No. | 127294-70-6 |
| Smiles | O(C)C1=C2N(C=C(C(O)=O)C(=O)C2=CC(F)=C1N3CC(NC)CCC3)C4CC4 |
| Relative Density. | 1.4 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 1 mg/mL (2.57 mM), Sonication is recommended.  | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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