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Anti-Cadherin 17/CDH17 Antibody (1M408)
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Catalog No. TMAY-03802
Alias cadherin 17, LI cadherin (liver-intestine)
Anti-Cadherin 17/CDH17 Antibody (1M408) is a Rabbit antibody targeting Cadherin 17/CDH17. Anti-Cadherin 17/CDH17 Antibody (1M408) can be used in ELISA.
Anti-Cadherin 17/CDH17 Antibody (1M408)
Anti-Cadherin 17/CDH17 Antibody (1M408)
😃Good
Catalog No. TMAY-03802Alias cadherin 17, LI cadherin (liver-intestine)
Anti-Cadherin 17/CDH17 Antibody (1M408) is a Rabbit antibody targeting Cadherin 17/CDH17. Anti-Cadherin 17/CDH17 Antibody (1M408) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Cadherin 17/CDH17 Antibody (1M408) is a Rabbit antibody targeting Cadherin 17/CDH17. Anti-Cadherin 17/CDH17 Antibody (1M408) can be used in ELISA. |
| Alias | cadherin 17, LI cadherin (liver-intestine) |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 1M408 |
| Reactivity | Rat |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Rat Cadherin-17 (rR Cadherin-17; TMPY-02919; P55281; Met1-Met786). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing of the encoding gene results in multiple transcript variants. Cadherin-17/LI-cadherin preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin-17 may thus contribute to the sorting of heterogeneous cell types and have a role in the morphological organization of liver and intestine. It's also involved in intestinal peptide transport. Experiments have reported the association between Cadherin-17/LI-cadherin and gastric cancer. Cadherin-17/LI-cadherin expression was detected in 63/94 of gastric adenocarcinomas in addition to intestinal metaplasia. The expression of Cadherin-17 tended to be associated with intestinal type carcinoma, and carcinomas with Cadherin-17 expression was significantly more frequent in advanced stage cases than in early stage. Cadherin-17 is also a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Rat Cadherin-17 Protein (TMPY-02919) |
| Antigen Species | Rat |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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