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GS-829845

Catalog No. T67905 CAS 1257705-09-1

GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-life than the parent.

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GS-829845, CAS 1257705-09-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 57.00
25 mg	In stock	$ 90.00
50 mg	In stock	Inquiry

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Purity: 99.78%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-life than the parent.

In vivo

Filgotinib did not alter metformin exposures, indicating that filgotinib and GS-829845 do not inhibit OCT2 and MATE1/2K at the clinical doses. Filgotinib was generally well-tolerated when administered alone or with the co-administered drugs in the studies. Results from these studies were the basis to enable the use of P-gp modulators and substrates of OCT2, MATE1, and MATE2K with filgotinib without the need for dose modifications in the current approved rheumatoid arthritis population.[2]

Molecular Weight	357.43
Formula	C17H19N5O2S
CAS No.	1257705-09-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (251.8 mM), Sonication is recommended.

References and Literature

1. Meng A, et al. Exposure-response relationships for the efficacy and safety of filgotinib and its metabolite GS-829845 in subjects with rheumatoid arthritis based on phase 2 and phase 3 studies. Br J Clin Pharmacol. 2022;88(7):3211-3221. 2. Hsueh CH, et al. Evaluation of the potential drug interactions mediated through P-gp, OCT2, and MATE1/2K with filgotinib in healthy subjects. Clin Transl Sci. 2022;15(2):361-370. 3. Namour F, et al. Filgotinib: A Clinical Pharmacology Review. Clin Pharmacokinet. 2022;61(6):819-832.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library

Related Products

Related compounds with same targets

Dehydrocrenatidine STAT3-IN-18 Abrocitinib JAK-IN-34 RO495 Pyridone 6 Ritlecitinib QL-1200186

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GS-829845 1257705-09-1 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Metabolism Stem Cells JAK Drug Metabolite GS 829845 GS829845 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.