Powder: -20°C for 3 years | In solvent: -80°C for 1 year
QD-394 is an inducer of reactive oxygen species (ROS) production.1It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to oxidized GSH (GSSG) ratio in MIA PaCa-2 pancreatic cancer cells when used at concentrations ranging from 0.5 to 10 μM. QD-394 is cytotoxic to MIA PaCa-2, PANC-1, and BxPC-3 cancer cells (IC50s = 0.64, 0.34, and 0.9 μM, respectively). QD-394 acts synergistically with napabucasin to reduce colony formation in MIA PaCa-2 cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 123.00 | |
5 mg | 35 days | $ 568.00 | |
10 mg | 35 days | $ 1,060.00 | |
25 mg | 35 days | $ 2,210.00 |
Description | QD-394 is an inducer of reactive oxygen species (ROS) production.1It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to oxidized GSH (GSSG) ratio in MIA PaCa-2 pancreatic cancer cells when used at concentrations ranging from 0.5 to 10 μM. QD-394 is cytotoxic to MIA PaCa-2, PANC-1, and BxPC-3 cancer cells (IC50s = 0.64, 0.34, and 0.9 μM, respectively). QD-394 acts synergistically with napabucasin to reduce colony formation in MIA PaCa-2 cells. |
Molecular Weight | 349.39 |
Formula | C19H19N5O2 |
CAS No. | 2132411-21-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 1 mg/lm
DMSO: 5 mg/mL
DMSO:PBS (pH 7.2) (1:20): 0.04 mg/mL
PBS (pH 7.2): Slightly soluble
DMF: 1 mg/lm
You can also refer to dose conversion for different animals. More
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QD-394 2132411-21-1 QD 394 QD394 inhibitor inhibit