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DPTN dihydrochloride

Catalog No. T72067 CAS 325767-87-1

DPTN dihydrochloride is a potent and selective A3AR antagonist with Ki values of 1.65, 9.61 and 8.53 nM in human, mouse and rat, respectively.

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DPTN dihydrochloride, CAS 325767-87-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 43.00
5 mg	In stock	$ 98.00
10 mg	In stock	$ 168.00
25 mg	In stock	$ 365.00
50 mg	In stock	$ 562.00
100 mg	In stock	$ 790.00
500 mg	In stock	$ 1,670.00

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Purity: 100%

Biological Description

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Description	DPTN dihydrochloride is a potent and selective A3AR antagonist with Ki values of 1.65, 9.61 and 8.53 nM in human, mouse and rat, respectively.
Targets&IC50	A3 (human):1.65 nM (Ki)
In vitro	DPTN dihydrochloride is a potent antagonist of human, mouse, and rat A3AR. However, compared with human A3AR, DPTN dihydrochloride has a weaker effect and reduced selectivity in mice and rats (approximately 20 times that of A2BAR).[1] The binding affinity test of DNPT (10 μM) on the cell membrane of transfected HEK293 cells showed that its Ki values for hA1, hA2A, hA2B and hA3 were 162±49, 121±42, 230±40 and 1.65±0.57 nM respectively[ 1]. The Ki values of DPTN dihydrochloride at A1, A2A, A2B and A3 receptors are 411, 830, 189 and 9.61 nM (mouse); 333, 1147, 163 and 8.53 nM (rat) respectively.[1]

Molecular Weight	459.39
Formula	C22H20Cl2N4OS
CAS No.	325767-87-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.30 mg/mL (5 mM), Sonication is recommended.

References and Literature

1. Gao ZG, et al. Pharmacological characterization of DPTN and other selective A3 adenosine receptor antagonists. Purinergic Signal. 2021 Dec;17(4):737-746.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Membrane Protein-targeted Compound Library Bioactive Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

GR79236 MRS 1754 Sulmazole PSB-603 Namodenoson Reversine 5-Iodotubercidin Adenosine antagonist-1

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Keywords

DPTN dihydrochloride 325767-87-1 GPCR/G Protein Neuroscience Adenosine Receptor DPTN Dihydrochloride DPTN DPTNdihydrochloride inhibitor inhibit

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