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Anti-MSH6 Antibody (3L662)
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Catalog No. TMAC-02651
Alias Sperm associated protein, p160, MutS-alpha 160 kDa subunit, mutS homolog 6, MutS alpha 160 kDa subunit, mutS (E. coli) homolog 6, MSH 6, HSAP, HNPCC5, HNPCC 5, hMSH6, GTMBP, GTBP, G/T mismatch binding protein, DNA mismatch repair protein Msh6
Anti-MSH6 Antibody (3L662) is a Rabbit antibody targeting MSH6. Anti-MSH6 Antibody (3L662) can be used in WB,IHC,IP.
Anti-MSH6 Antibody (3L662)
Anti-MSH6 Antibody (3L662)
😃Good
Catalog No. TMAC-02651Alias Sperm associated protein, p160, MutS-alpha 160 kDa subunit, mutS homolog 6, MutS alpha 160 kDa subunit, mutS (E. coli) homolog 6, MSH 6, HSAP, HNPCC5, HNPCC 5, hMSH6, GTMBP, GTBP, G/T mismatch binding protein, DNA mismatch repair protein Msh6
Anti-MSH6 Antibody (3L662) is a Rabbit antibody targeting MSH6. Anti-MSH6 Antibody (3L662) can be used in WB,IHC,IP.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $297 | 7-10 days | |
| 100 μL | $497 | 7-10 days |
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Product Introduction
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Antigen Details
Chemical Properties
| Description | Anti-MSH6 Antibody (3L662) is a Rabbit antibody targeting MSH6. Anti-MSH6 Antibody (3L662) can be used in WB,IHC,IP. |
| Synonyms | Sperm associated protein, p160, MutS-alpha 160 kDa subunit, mutS homolog 6, MutS alpha 160 kDa subunit, mutS (E. coli) homolog 6, MSH 6, HSAP, HNPCC5, HNPCC 5, hMSH6, GTMBP, GTBP, G/T mismatch binding protein, DNA mismatch repair protein Msh6 |
| Ig Type | IgG |
| Reactivity | Human,Mouse |
| Verified Activity | 1. Western blot analysis of MSH6 on Hela cell lysates using anti-MSH6 at 1/500 dilution. 2. Immunohistochemical analysis of paraffin-embedded human lung tissue using anti-MSH6 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-MSH6 antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-MSH6 antibody. Counter stained with hematoxylin. |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC: 1:50-200; IP: 1:10-50 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 153 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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