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N1-Methylpseudouridine-5'-triphosphate
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Catalog No. T73735Cas No. 1428903-59-6
Alias 1-Methylpseudouridine-5'-triphosphate
N1-Methylpseudouridine-5'-triphosphate is a modified nucleotide derivative commonly used to explore RNA modification, synthesis, and function, and can replace UTP in synthesis thereby improving RNA stability and reducing immunogenicity.
N1-Methylpseudouridine-5'-triphosphate
😃Good
Catalog No. T73735Alias 1-Methylpseudouridine-5'-triphosphateCas No. 1428903-59-6
N1-Methylpseudouridine-5'-triphosphate is a modified nucleotide derivative commonly used to explore RNA modification, synthesis, and function, and can replace UTP in synthesis thereby improving RNA stability and reducing immunogenicity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $118 | 7-10 days | |
| 10 mg | $188 | 7-10 days | |
| 25 mg | $289 | 7-10 days | |
| 50 mg | $428 | 7-10 days | |
| 100 mg | $639 | 7-10 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | N1-Methylpseudouridine-5'-triphosphate is a modified nucleotide derivative commonly used to explore RNA modification, synthesis, and function, and can replace UTP in synthesis thereby improving RNA stability and reducing immunogenicity. |
| In vitro | In in vitro experiments, N1-Methylpseudouridine-5'-triphosphate significantly enhanced the translation initiation and elongation processes by inhibiting the phosphorylation of eIF2α and increasing ribosome density. Additionally, mRNA incorporating N1-Methylpseudouridine-5′-triphosphate exhibited higher translation efficiency and lower immunogenicity in mammalian cell lines, such as HEK293T cells [1]. |
| Alias | 1-Methylpseudouridine-5'-triphosphate |
| Molecular Weight | 498.17 |
| Formula | C10H17N2O15P3 |
| Cas No. | 1428903-59-6 |
| Smiles | O[C@H]1[C@@H](O[C@H](COP(OP(OP(=O)(O)O)(=O)O)(=O)O)[C@H]1O)C=2C(=O)NC(=O)N(C)C2 |
Storage & Solubility Information
| Storage | keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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