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Arimoclomol maleate

Name: Arimoclomol maleate
Brand: TargetMol
SKU: T13554
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13554Cas No. 289893-26-1

Alias BRX-220

Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.

Arimoclomol maleate

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Purity: 99.98%

Catalog No. T13554Alias BRX-220Cas No. 289893-26-1

Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.

Pack Size	Price	Availability
5 mg	$39	In Stock
10 mg	$72	In Stock
25 mg	$147	In Stock
50 mg	$247	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock

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Batch Information

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Purity:99.98%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.
In vivo	Arimoclomol, administered for 5 d, has a protective effect against CCK-induced acute pancreatitis. Repeated CCK treatment results in the typical laboratory and morphological changes of experimentally induced pancreatitis. The pancreatic levels of HSP60 and HSP72 are significantly increased in the animals treated with Arimoclomol [1]. Arimoclomol is a co-inducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis (ALS), the most common form of motor neuron disease [2].
Synonyms	BRX-220

Chemical Properties

Molecular Weight	429.85
Formula	C₁₈H₂₄ClN₃O₇
Cas No.	289893-26-1
Smiles	OC(=O)\C=C/C(O)=O.O[C@@H](CO\N=C(/Cl)c1ccc[n+]([O-])c1)CN1CCCCC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (581.60 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (11.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3264 mL	11.6320 mL	23.2639 mL	116.3196 mL
5 mM	0.4653 mL	2.3264 mL	4.6528 mL	23.2639 mL
10 mM	0.2326 mL	1.1632 mL	2.3264 mL	11.6320 mL
20 mM	0.1163 mL	0.5816 mL	1.1632 mL	5.8160 mL
50 mM	0.0465 mL	0.2326 mL	0.4653 mL	2.3264 mL
100 mM	0.0233 mL	0.1163 mL	0.2326 mL	1.1632 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc