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AMG 333

Name: AMG 333
Brand: TargetMol
SKU: T5479
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5479Cas No. 1416799-28-4

Alias AMG-333

AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.

AMG 333

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Purity: 99.95%

Catalog No. T5479Alias AMG-333Cas No. 1416799-28-4

AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$40	In Stock	In Stock
10 mg	$68	In Stock	In Stock
25 mg	$143	In Stock	In Stock
50 mg	$247	In Stock	In Stock
100 mg	$367	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.95%

Color:White

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COA HNMR LCMS

Product Introduction

AMG 333 AI Summary

AMG 333 exhibits bioactivities related to TRPM8 modulation, demonstrating antagonist activity with an IC50 of 20.0 nM in rat TRPM8 and 13.0 nM in human TRPM8. In vivo, it reduces icilin-induced wet dog shaking in rats, indicating effective TRPM8 antagonism. Cardiovascular toxicity tests on isolated rabbit hearts identified a NOAEL greater than 10.0 μM. The compound also inhibits TRPV1, TRPV3, TRPV4, and TRPA1 with IC50 values exceeding 20,000 nM and 40,000 nM, respectively. Additionally, the compound influences cell growth rates variably depending on the cell type: in HEK293T cells, growth rates increase consistently from 0.5 to 0.92; in U2OS cells, the increase ranges from -0.99 to 0.96; and in human fibroblasts, growth rates range from -1.0 to 1.0, indicating a complex interaction with cell viability..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.
Targets&IC50	TRPM8:13 nM
Synonyms	AMG-333

Chemical Properties

Molecular Weight	453.32
Formula	C₂₀H₁₂F₅N₃O₄
Cas No.	1416799-28-4
Smiles	OC(=O)c1ccc(nc1)C(=O)N[C@@H](c1ccc(OC(F)(F)F)c(F)c1)c1ncccc1F
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (275.74 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2059 mL	11.0297 mL	22.0595 mL	110.2974 mL
5 mM	0.4412 mL	2.2059 mL	4.4119 mL	22.0595 mL
10 mM	0.2206 mL	1.1030 mL	2.2059 mL	11.0297 mL
20 mM	0.1103 mL	0.5515 mL	1.1030 mL	5.5149 mL
50 mM	0.0441 mL	0.2206 mL	0.4412 mL	2.2059 mL
100 mM	0.0221 mL	0.1103 mL	0.2206 mL	1.1030 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc