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Anti-RACGAP1 Antibody (8E200)
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Catalog No. TMAB-12029
Anti-RACGAP1 Antibody (8E200) is a Rabbit antibody targeting RACGAP1. Anti-RACGAP1 Antibody (8E200) can be used in IHC-P,IHC-Fr,IF.
Anti-RACGAP1 Antibody (8E200)
Anti-RACGAP1 Antibody (8E200)
😃Good
Catalog No. TMAB-12029
Anti-RACGAP1 Antibody (8E200) is a Rabbit antibody targeting RACGAP1. Anti-RACGAP1 Antibody (8E200) can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $151 | 7-10 days | 7-10 days | |
| 50 μL | $263 | 7-10 days | 7-10 days | |
| 100 μL | $473 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-RACGAP1 Antibody (8E200) is a Rabbit antibody targeting RACGAP1. Anti-RACGAP1 Antibody (8E200) can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Clone | 8E200 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. |
| Tissue Specificity | Highly expressed in testis, thymus and placenta. Expressed at lower levels in spleen and peripheral blood lymphocytes. In testis, expression is restricted to germ cells with the highest levels of expression found in spermatocytes. Expression is regulated in a cell cycle-dependent manner and peaks during G2/M phase. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis. |
| Immunogen | A synthesized peptide: human RacGAP1 |
| Antigen Species | Human |
| Gene Name | RACGAP1 |
| Gene ID | |
| Protein Name | Rac GTPase-activating protein 1 |
| Uniprot ID | |
| Function | Component of the centralspindlin complex that serves asa microtubule-dependent and Rho-mediated signaling required for themyosin contractile ring formation during the cell cyclecytokinesis. Plays key roles in controlling cell growth anddifferentiation of hematopoietic cells through mechanisms otherthan regulating Rac GTPase activity. Also involved in theregulation of growth-related processes in adipocytes and myoblasts.May be involved in regulating spermatogenesis and in the RACGAP1pathway in neuronal proliferation. Shows strong GAP (GTPaseactivation) activity towards CDC42 and RAC1 and less towards RHOA.Essential for the early stages of embryogenesis. May play a role inregulating cortical activity through RHOA during cytokinesis. Mayparticipate in the regulation of sulfate transport in male germcells. |
| Molecular Weight | Theoretical: 71 kDa. Actual: 71 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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