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Vamotinib

Name: Vamotinib
Brand: TargetMol
SKU: T63746
Price: 108 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T63746Cas No. 1416241-23-0

Alias PF-114

Vamotinib (PF-114) is an orally active and specific tyrosine kinase inhibitor with antiproliferative and antitumour activity.Vamotinib inhibits the phosphorylation of BCR/ABL and BCR/ABL-T315I, which promotes apoptosis. Vamotinib is used to study drug-resistant Philadelphia chromosome-positive (Ph+) leukaemia and Alzheimer's disease.

Vamotinib

🥰Excellent

Purity: 99.64%

Catalog No. T63746Alias PF-114Cas No. 1416241-23-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$108	In Stock	In Stock
5 mg	$272	In Stock	In Stock
10 mg	$446	In Stock	In Stock
25 mg	$796	In Stock	In Stock
50 mg	$1,090	In Stock	In Stock
100 mg	$1,490	-	In Stock
200 mg	$1,980	-	In Stock
1 mL x 10 mM (in DMSO)	$319	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.64%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Vamotinib (PF-114) is an orally active and specific tyrosine kinase inhibitor with antiproliferative and antitumour activity.Vamotinib inhibits the phosphorylation of BCR/ABL and BCR/ABL-T315I, which promotes apoptosis. Vamotinib is used to study drug-resistant Philadelphia chromosome-positive (Ph+) leukaemia and Alzheimer's disease.
Targets&IC50	BCR-ABL:0.49 nM, Abl (G250E):7.4 nM, Abl (F317I):2.0 nM, Abl (Q252H):12 nM, Abl (H396P):1.0 nM, Abl (E255K):9.5 nM, Abl (T315I):0.78 nM, Abl (Y253F):4.1 nM
In vitro	Vamotinib (0-1000 nM) inhibits the autophosphorylation of BCR/ABL and BCR/ABL-T315I in a dose-dependent manner. Additionally, it can suppress the growth of Ph+ patient-derived cell lines, including K562, KCL-22, SupB15, Tom-1, BV-173, as well as Ph+ PD-LTC cells with non-mutated resistance and T315I mutation[1].
In vivo	In female BALB/cAnNRj-Foxn1nu mice (K562 nude mouse xenograft model), Vamotinib (25/40 mg/kg, oral gavage; 14 days) resulted in a 100% reduction in average tumor volume within 4 weeks.
Synonyms	PF-114

Chemical Properties

Molecular Weight	532.56
Formula	C₂₉H₂₇F₃N₆O
Cas No.	1416241-23-0
Smiles	CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3nnc4ccccn34)cc2C(F)(F)F)CC1

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (56.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 2 mg/mL (3.76 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8777 mL	9.3886 mL	18.7772 mL	93.8861 mL
5 mM	0.3755 mL	1.8777 mL	3.7554 mL	18.7772 mL
10 mM	0.1878 mL	0.9389 mL	1.8777 mL	9.3886 mL
20 mM	0.0939 mL	0.4694 mL	0.9389 mL	4.6943 mL
50 mM	0.0376 mL	0.1878 mL	0.3755 mL	1.8777 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc