keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vamotinib (PF-114) is an orally active and specific tyrosine kinase inhibitor with antiproliferative and antitumour activity.Vamotinib inhibits the phosphorylation of BCR/ABL and BCR/ABL-T315I, which promotes apoptosis. Vamotinib is used to study drug-resistant Philadelphia chromosome-positive (Ph+) leukaemia and Alzheimer's disease.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 328.00 | |
10 mg | In stock | $ 538.00 | |
25 mg | In stock | $ 1,080.00 | |
50 mg | In stock | $ 1,730.00 | |
100 mg | In stock | $ 2,780.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 388.00 |
Description | Vamotinib (PF-114) is an orally active and specific tyrosine kinase inhibitor with antiproliferative and antitumour activity.Vamotinib inhibits the phosphorylation of BCR/ABL and BCR/ABL-T315I, which promotes apoptosis. Vamotinib is used to study drug-resistant Philadelphia chromosome-positive (Ph+) leukaemia and Alzheimer's disease. |
Targets&IC50 | Abl (F317I):2.0 nM, Abl (T315I):0.78 nM, Abl (Y253F):4.1 nM, Abl (E255K):9.5 nM, BCR-ABL:0.49 nM, Abl (G250E):7.4 nM, Abl (H396P):1.0 nM, Abl (Q252H):12 nM |
In vitro | Vamotinib (0-1000 nM) inhibits the autophosphorylation of BCR/ABL and BCR/ABL-T315I in a dose-dependent manner. Additionally, it can suppress the growth of Ph+ patient-derived cell lines, including K562, KCL-22, SupB15, Tom-1, BV-173, as well as Ph+ PD-LTC cells with non-mutated resistance and T315I mutation[1]. |
In vivo | In female BALB/cAnNRj-Foxn1nu mice (K562 nude mouse xenograft model), Vamotinib (25/40 mg/kg, oral gavage; 14 days) resulted in a 100% reduction in average tumor volume within 4 weeks. |
Synonyms | PF-114 |
Molecular Weight | 532.56 |
Formula | C29H27F3N6O |
CAS No. | 1416241-23-0 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (56.33 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Vamotinib 1416241-23-0 Angiogenesis Apoptosis Cytoskeletal Signaling Tyrosine Kinase/Adaptors Tyrosine Kinases Bcr-Abl PF-114 inhibitor inhibit