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Tioconazole

Name: Tioconazole
Brand: TargetMol
SKU: T0146
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0146Cas No. 65899-73-2

Alias Vagistat, UK-20349

Tioconazole (Vagistat) is a synthetic imidazole derivative, inhibits cell wall synthesis by inhibiting the biosynthesis of ergosterol or other sterols, damaging the fungal cell membrane, altering its permeability, and promoting loss of essential intracellular elements.

Tioconazole

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Purity: 99.57%

Catalog No. T0146Alias Vagistat, UK-20349Cas No. 65899-73-2

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$30	In Stock	In Stock
500 mg	$45	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.57%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Tioconazole AI Summary

Tioconazole inhibits human Cytochrome P450 17A1 activity in vitro with a Ki value of 505.0 nM, indicating its potential role in steroid hormone biosynthesis inhibition. It exhibits bioactivity across various assays, showing potency in inhibiting ROR gamma transcriptional activity, the vitamin D receptor (VDR), malarial parasite plastid, USP1/UAF1, tyrosyl-DNA phosphodiesterase 1 (TDP1), Lassa Virus, and Ebola Virus, and affects DNA re-replication and cell viability in both normal and cancer cells. Tioconazole also impacts the entry of Ebola Virus into cells and demonstrates antifungal activity against multiple Candida species, with MIC values ranging from 4.0 to 8.0 µg/mL. It displays moderate liver toxicity and affects liver enzyme levels. Additionally, it shows high solubility in a pH 6.5 phosphate buffer containing 5% DMSO and exhibits a variety of bioactivities, including notable cytotoxicity across various cell lines, with IC50 values varying from 530.0 nM to 77380.0 nM. It is active against diseases like malaria, leishmaniasis, Chagas disease, and HAT. The compound also inhibits SARS-CoV-2 induced cytotoxicity in cells, though with limited efficiency, and partially inhibits SARS-CoV-2 3CL-Pro protease. In enzymatic assays, Tioconazole inhibits human HDAC6 and ATG4A/B enzymes, suggesting its potential as an autophagy regulator. It additionally shows diverse bioactivities across various receptor types and mixed agonist/antagonist activities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tioconazole (Vagistat) is a synthetic imidazole derivative, inhibits cell wall synthesis by inhibiting the biosynthesis of ergosterol or other sterols, damaging the fungal cell membrane, altering its permeability, and promoting loss of essential intracellular elements.
Synonyms	Vagistat, UK-20349

Chemical Properties

Molecular Weight	387.71
Formula	C₁₆H₁₃Cl₃N₂OS
Cas No.	65899-73-2
Smiles	C(CN1C=CN=C1)(OCC2=C(Cl)SC=C2)C3=C(Cl)C=C(Cl)C=C3
Relative Density.	1.44g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 50 mg/mL (128.96 mM), Sonication is recommended.

Ethanol: 72 mg/mL (185.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.5792 mL	12.8962 mL	25.7925 mL	128.9624 mL
5 mM	0.5158 mL	2.5792 mL	5.1585 mL	25.7925 mL
10 mM	0.2579 mL	1.2896 mL	2.5792 mL	12.8962 mL
20 mM	0.1290 mL	0.6448 mL	1.2896 mL	6.4481 mL
50 mM	0.0516 mL	0.2579 mL	0.5158 mL	2.5792 mL
100 mM	0.0258 mL	0.1290 mL	0.2579 mL	1.2896 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc