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(R)-ZINC-3573

Name: (R)-ZINC-3573
Brand: TargetMol
SKU: T29221
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T29221Cas No. 2089389-15-9

Alias ZINC 3573

(R)-ZINC-3573 is a potent and highly selective MRGPRX2 probe that activates endogenous MRGPRX2 in a human mast cell line, inducing degranulation and calcium release.

(R)-ZINC-3573

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Purity: 99.75%

Catalog No. T29221Alias ZINC 3573Cas No. 2089389-15-9

(R)-ZINC-3573 is a potent and highly selective MRGPRX2 probe that activates endogenous MRGPRX2 in a human mast cell line, inducing degranulation and calcium release.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$39	In Stock	In Stock
5 mg	$64	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$228	In Stock	In Stock
50 mg	$343	In Stock	In Stock
100 mg	$497	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$70	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.75%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

(R)-ZINC-3573 AI Summary

(R)-ZINC-3573 exhibits a broad spectrum of bioactivities, showing varying effects on cell viability across different cell types. For instance, in HEK293T cells, it can either inhibit or promote growth (Growth Rates 0.0 and 1.0, respectively). Similar mixed effects are observed in human fibroblast cells and U2OS cells, indicating cell-type-specific responses. The compound targets multiple GPCRs, including various serotonin, dopamine, adrenergic, and histamine receptors, as well as GABA, opioid receptors, Sigma receptors, and transporters such as DAT and NET. It also shows specific bioactivity towards KinomeScan targets (BTK, MAPK10, and MAPK8) and interacts with MRGPRX2 with an EC50 value of 740.0 nM in the PRESTO-Tango assay. Additionally, it affects the thermal stability of different protein domains, causing slight increases or decreases in stability (Delta TM ranging from 0.003338 to 0.6544 C increase and -0.4767 to -0.8674 C decrease). These comprehensive data suggest that (R)-ZINC-3573 has the potential for significant modulatory effects on various neurotransmitter systems and protein interactions, which may have therapeutic implications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	(R)-ZINC-3573 is a potent and highly selective MRGPRX2 probe that activates endogenous MRGPRX2 in a human mast cell line, inducing degranulation and calcium release.
Synonyms	ZINC 3573

Chemical Properties

Molecular Weight	307.39
Formula	C₁₈H₂₁N₅
Cas No.	2089389-15-9
Smiles	CN(C)[C@@H]1CCN(C1)c1cc(nc2ccnn12)-c1ccccc1
Relative Density.	1.23 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (81.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (6.51 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2532 mL	16.2660 mL	32.5320 mL	162.6598 mL
5 mM	0.6506 mL	3.2532 mL	6.5064 mL	32.5320 mL
10 mM	0.3253 mL	1.6266 mL	3.2532 mL	16.2660 mL
20 mM	0.1627 mL	0.8133 mL	1.6266 mL	8.1330 mL
50 mM	0.0651 mL	0.3253 mL	0.6506 mL	3.2532 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc