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Efalizumab, a novel potent regulator of T cells, is a humanized LFA-1 α subunit (CD11a) monoclonal antibody. Efalizumab has inhibitory effects on T cell activation, skin T cell transport, and T cell adhesion to keratinocytes, and can be used to study plaque psoriasis and psoriatic arthritis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 255.00 | |
5 mg | In stock | $ 643.00 | |
10 mg | In stock | $ 987.00 | |
25 mg | In stock | $ 1,460.00 | |
50 mg | In stock | $ 1,970.00 | |
100 mg | In stock | $ 2,660.00 |
Description | Efalizumab, a novel potent regulator of T cells, is a humanized LFA-1 α subunit (CD11a) monoclonal antibody. Efalizumab has inhibitory effects on T cell activation, skin T cell transport, and T cell adhesion to keratinocytes, and can be used to study plaque psoriasis and psoriatic arthritis. |
In vitro | Efalizumab, at concentrations ranging from 78 ng/mL to 5 mg/mL, promotes leukocytosis and reduces the expression of LFA-1 on T cells within the peripheral blood. Additionally, at the same concentration levels, it inhibits the proliferation of peripheral blood mononuclear cells (PBMC) that is stimulated by plate-bound anti-CD3. |
In vivo | Efalizumab exhibits side effects including bacterial sepsis, viral meningitis, invasive fungal disease, and progressive multifocal leukoencephalopathy (PML), a brain infection caused by the reactivation of latent JC virus infection[2]. |
Synonyms | Hu1124, HU 1124 |
Molecular Weight | N/A |
CAS No. | 214745-43-4 |
store at low temperature
store at -80°C
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Efalizumab 214745-43-4 Cytoskeletal Signaling Integrin Hu1124 HU-1124 HU 1124 HU1124 inhibitor inhibit