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Efalizumab
(Synonyms: Hu1124, HU 1124) Copy Product Info
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Synonyms: Hu1124, HU 1124
Catalog No. T76924 Copy Product Info
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Efalizumab, a novel potent regulator of T cells, is a humanized LFA-1 α subunit (CD11a) monoclonal antibody. Efalizumab has inhibitory effects on T cell activation, skin T cell transport, and T cell adhesion to keratinocytes, and can be used to study plaque psoriasis and psoriatic arthritis.
Cas No. 214745-43-4
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $198 | In Stock | In Stock | |
| 5 mg | $513 | In Stock | In Stock | |
| 10 mg | $819 | - | In Stock | |
| 25 mg | $1,220 | - | In Stock | |
| 50 mg | $1,630 | - | In Stock | |
| 100 mg | $2,220 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.77% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
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| Description | Efalizumab, a novel potent regulator of T cells, is a humanized LFA-1 α subunit (CD11a) monoclonal antibody. Efalizumab has inhibitory effects on T cell activation, skin T cell transport, and T cell adhesion to keratinocytes, and can be used to study plaque psoriasis and psoriatic arthritis. |
| In vitro | Efalizumab, at concentrations ranging from 78 ng/mL to 5 mg/mL, promotes leukocytosis and reduces the expression of LFA-1 on T cells within the peripheral blood. Additionally, at the same concentration levels, it inhibits the proliferation of peripheral blood mononuclear cells (PBMC) that is stimulated by plate-bound anti-CD3. |
| In vivo | Efalizumab exhibits side effects including bacterial sepsis, viral meningitis, invasive fungal disease, and progressive multifocal leukoencephalopathy (PML), a brain infection caused by the reactivation of latent JC virus infection[2]. |
| Endotoxin | <1.0 EU/mg |
| Synonyms | Hu1124, HU 1124 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | Integrin aL/ITGAL/CD11a |
| Molecular Weight | 146.14 kDa |
| Cas No. | 214745-43-4 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Efalizumab chemical structure | Efalizumab in vivo | Efalizumab in vitro | Efalizumab molecular weight
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