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10β,17β-dihydroxyestra-1,4-dien-3-one (Synonyms: DHED)

Name: 10β,17β-dihydroxyestra-1,4-dien-3-one
Brand: TargetMol
SKU: T10036
Price: 99 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T10036 Copy Product Info

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10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-selective prodrug of 17β-estradiol, which has neuroprotective effects, improves cognitive dysfunction, and can be used to study brain damage.

10β,17β-dihydroxyestra-1,4-dien-3-one

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Catalog No. T10036

Synonyms DHED

Cas No. 549-02-0

Pack Size	Price	USA Stock	Global Stock	Quantity
2 mg	$99	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-selective prodrug of 17β-estradiol, which has neuroprotective effects, improves cognitive dysfunction, and can be used to study brain damage.
In vivo	The effect of 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) on PR expression has also been evaluated on animals. PR expression in brains taken from morphine-treated rats manifested the same response to 10β,17β-dihydroxyestra-1,4-dien-3-one or EE as in OVX rats not treated with morphine. These animals were treated with the test compounds (10β,17β-dihydroxyestra-1,4-dien-3-one 30 and 100μg/kg, EE 200μg/kg, and vehicle) via oral gavage twice per day. As indicated by optical density on film exposures, that induction of the highly estrogen-responsive gene was three fold higher in the 10β,17β-dihydroxyestra-1,4-dien-3-one - and EE-treated groups than in the vehicle-treated animals.
Synonyms	DHED

Chemical Properties

Molecular Weight	288.38
Formula	C₁₈H₂₄O₃
Cas No.	549-02-0
Smiles	O[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@H](O)CC4)[H])(CCC1=CC(=O)C=C2)[H])[H]
Relative Density.	1.24 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Store at low temperature | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (277.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (11.44 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4676 mL	17.3382 mL	34.6765 mL	173.3823 mL
5 mM	0.6935 mL	3.4676 mL	6.9353 mL	34.6765 mL
10 mM	0.3468 mL	1.7338 mL	3.4676 mL	17.3382 mL
20 mM	0.1734 mL	0.8669 mL	1.7338 mL	8.6691 mL
50 mM	0.0694 mL	0.3468 mL	0.6935 mL	3.4676 mL
100 mM	0.0347 mL	0.1734 mL	0.3468 mL	1.7338 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

EstrogenReceptorEstrogen Receptor/ERREstrogen ReceptorERR10β,17β-dihydroxyestra-1,4-dien-3-one10β,17βdihydroxyestra1,4dien3one10β,17β dihydroxyestra 1,4 dien 3 one10beta,17beta-dihydroxyestra-1,4-dien-3-one10b,17b-dihydroxyestra-1,4-dien-3-one

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