Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Z164597606 is a compound that acts as a selective inhibitor of the enzyme Butyrylcholinesterase (BChE), with IC50 values of 1.3 μM and 1.7 μM for equine BChE and human BChE, respectively. Through a π-π stacking interaction, Z164597606 specifically interacts with the amino acid Trp82 of human BChE. This compound has potential applications in Alzheimer's disease research [1] [2].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Z164597606 is a compound that acts as a selective inhibitor of the enzyme Butyrylcholinesterase (BChE), with IC50 values of 1.3 μM and 1.7 μM for equine BChE and human BChE, respectively. Through a π-π stacking interaction, Z164597606 specifically interacts with the amino acid Trp82 of human BChE. This compound has potential applications in Alzheimer's disease research [1] [2]. |
In vitro | Z164597606 at a concentration of 10 μM potently reduces BChE activity while demonstrating minimal inhibition (not exceeding 30%) of AChE, according to study [1]. At concentrations ranging from 0.5 to 20 μM, Z164597606 likely targets the catalytic anionic site (CAS) of BChE, as inferred from Lineweaver-Burk reciprocal plots [1]. Furthermore, Z164597606 has been shown to be non-toxic to the neuronal cell line SH-SY5Y at concentrations of 10 and 50 μM [1]. |
Molecular Weight | 365.38 |
Formula | C20H19N3O4 |
CAS No. | 1050587-57-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Z164597606 1050587-57-9 inhibitor inhibit