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Anti-IL-3R alpha/CD123 Antibody-APC (8N292)
🥰Excellent
Catalog No. TMAY-00941A
Anti-IL-3R alpha/CD123 Antibody-APC (8N292) is a APC-conjugated Mouse antibody targeting IL-3R alpha/CD123. Anti-IL-3R alpha/CD123 Antibody-APC (8N292) can be used in FCM.
Anti-IL-3R alpha/CD123 Antibody-APC (8N292)
Anti-IL-3R alpha/CD123 Antibody-APC (8N292)
🥰Excellent
Catalog No. TMAY-00941A
Anti-IL-3R alpha/CD123 Antibody-APC (8N292) is a APC-conjugated Mouse antibody targeting IL-3R alpha/CD123. Anti-IL-3R alpha/CD123 Antibody-APC (8N292) can be used in FCM.
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| Description | Anti-IL-3R alpha/CD123 Antibody-APC (8N292) is a APC-conjugated Mouse antibody targeting IL-3R alpha/CD123. Anti-IL-3R alpha/CD123 Antibody-APC (8N292) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2b |
| Clone | 8N292 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human IL3RA expression on KG-1 cells. Cells were stained with APC-conjugated anti-Human IL3RA. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL3RA (rh IL3RA; TMPY-01410; NP_002174.1; Met1-Arg305) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 5 subfamily. The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. The WSXWS motif of IL3RA appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box one motif of IL3RA is required for JAK interaction and/or activation. IL3RA represents a unique marker for primitive leukemic stem cells. Targeting of IL3RA may be a promising strategy for the preferential ablation of AML cells. Aberrant IL3RA expression is a good marker for monitoring of minimal residual disease. IL3RA is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. Recent studies have shown that interleukin-3 receptor alpha (CD123) is highly expressed on leukemia stem cells of patients with acute myeloid leukemia, and is correlated with tumor load and poor prognosis. CD123 was highly expressed in the bone marrow of the patients with myelodysplastic syndrome (MDS), significantly correlated with the proportion of bone marrow blasts, and thus might be the marker of MDS malignant clone. IL3RA is also a useful new marker for distinguishing B-cell disorders with circulating villous lymphocytes as its expression is characteristic of typical hairy cell leukemia (HCL) with high sensitivity and specificity. |
| Conjucates | APC |
| Others Formats | Unconjugated/FITC/PE |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Human IL3RA Protein (TMPY-01410) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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