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Chromatin/Epigenetic

DNA Methyltransferase

(97)

Epigenetic Reader Domain

HIF/HIF Prolyl-Hydroxylase

(236)

Histone Acetyltransferase

(135)

Histone Demethylase

(209)

Histone Methyltransferase

Methionine Adenosyltransferase (MAT)

PI3K/Akt/mTOR signaling

AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.

Filter HomeSignaling PathwaysPI3K/Akt/mTOR signaling-Chromatin/EpigeneticAMPK

MK8722

T160991394371-71-1

MK8722 is an effective and systemic activator of pan-AMPK.

AMPK

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Doxorubicin hydrochloride

NSC 123127, Hydroxydaunorubicin hydrochloride, DOX hydrochloride, Adriamycin HCl

T102025316-40-9

Doxorubicin hydrochloride is an anthracycline antibiotic with cytotoxic and antitumor activity. It is an effective inhibitor of human DNA topoisomerase I and II, with IC50 values of 0.8 μM and 2.67 μM, respectively. In addition to inhibiting DNA topoisomerases, it can reduce the phosphorylation of AMPK and its downstream target, acetyl-CoA carboxylase. Doxorubicin hydrochloride also induces apoptosis and autophagy. In animal studies, it is commonly used to induce models of acute renal failure, chronic kidney injury, and heart failure.

ADC Cytotoxin AMPK Antibacterial Antibiotic Apoptosis Autophagy HBV HIV Protease Mitophagy Topoisomerase

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Metformin

1,1-Dimethylbiguanide

T8526657-24-9

Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is commonly used in type 2 diabetes research.

AMPK Apoptosis Autophagy Mitophagy mTOR

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Dorsomorphin

Compound C, BML-275

T1977866405-64-3

Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive. Dorsomorphin inhibits the BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin induces autophagy, and possesses antitumor activity.

AMPK Autophagy TGF-beta/Smad

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Metformin hydrochloride

Metformin HCl, 1,1-Dimethylbiguanide hydrochloride, 1, 1-Dimethylbiguanide hydrochloride

T07401115-70-4

Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride), a widely used anti-diabetic drug, exhibits potential anti-Y properties by inhibiting the proliferation of various Y cells, including colon and prostate.

AMPK Apoptosis Autophagy Mitophagy mTOR

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Dorsomorphin dihydrochloride

Dorsomorphin (Compound C) 2HCl, Compound C dihydrochloride, Compound C 2HCl, BML-275 dihydrochloride, BML-275 2HCl

T61461219168-18-9

Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on structurally related kinases.

AMPK Autophagy TGF-beta/Smad

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MK-0626

MK0626

T68863690257-74-0

MK-0626 is an orally available dipeptidyl peptidase IV (DPP-4) inhibitor that attenuates hepatic steatosis and accumulation by enhancing AMPK activity.MK-0626 attenuates TAC-induced diabetic pancreatic islet injury by restoring the expression of GLP-1R.MK-0626 is able to increase circulating endothelial progenitor cell numbers and endothelial-type nitric oxide synthase expression by promoting neoangiogenesis.

AMPK Glucagon Receptor

$989

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RMC-7977

T812632765082-12-8

RMC-7977 is a highly selective inhibitor of the active (GTP-bound) forms of KRAS, HRAS, and NRAS with anticancer activity for the study of solid tumors with KRAS G12C mutations.

AMPK Apoptosis ERK Kras PARP Raf Ras S6 Kinase

$257

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Glycycoumarin

TN170294805-82-0

Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.

AMPK Autophagy Cytochromes P450 JNK Nrf2

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Doxorubicin

Hydroxydaunorubicin, DOX, Adriamycin

T145623214-92-8

Doxorubicin (Adriamycin) is a fluorescent anthracycline antitumor antibiotic that inhibits Topoisomerase I/II, induces apoptosis and autophagy, downregulates the AMPK signaling pathway, and is commonly used in cancer chemotherapy as well as in models of nephritis and heart failure.

ADC Cytotoxin AMPK Topoisomerase

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AICAR

NSC105823, AICAR (Acadesine), AICA Riboside, Acadesine

T14772627-69-2

AICAR (Acadesine) is an AMPK activator. AICAR has the functions of metabolic regulation, muscle function regulation, anti-cancer effect, neuroprotection and anti-aging.

AMPK Autophagy Endogenous Metabolite Mitophagy YAP

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A-769662

A 769662

T2468844499-71-4

A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).

AMPK Fatty Acid Synthase

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[6]-Gingerol

gingerol, 6-Gingerol, (S)-(+)-[6]Gingerol

T340523513-14-6

[6]-Gingerol ((S)-(+)-[6]Gingerol), an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bowel, among other tissues.

AMPK Apoptosis

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Bempedoic acid

ETC-1002, ETC1002, ETC 1002, ESP-55016

T3625738606-46-7

Bempedoic acid (ETC1002) is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies. Bempedoic acid(ETC1002) is absorbed rapidly in the small intestine and enters the liver through cell surface receptors different from those transporters that selectively take up statins. Bempedoic acid(ETC1002) is a regulator of lipid and carbohydrate metabolism.

AMPK ATP Citrate Lyase

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Aldometanib

Compound IA-47 (Br- base 2246625-81-8)

T601222904601-67-6

Aldometanib (LXY-05-029) is an orally active aldolase inhibitor that prevents FBP from binding to v-ATPase-associated aldolase and activates lysosomal AMPK, useful in metabolic homeostasis research [1].

AMPK

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MOTS-c(Human) Acetate（1627580-64-6 free）

TP2312

MOTS-c(Human) Acetate is a mitochondrial-derived peptide. MOTS-c(human) acetate induces the accumulation of AMP analog AICAR, increases activation of AMPK and expression of its downstream GLUT4. MOTS-c(human) acetate induces glucose uptake and improves insulin sensitivity. MOTS-c(human) acetate has implications in the regulation of obesity, diabetes, exercise, and longevity.

AMPK

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Epiberberine

T5S23616873-09-2

1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways during 3T3-L1 adipocyte differentiation. 3. Epiberberine, as the brightest FSA emitter among the alkaloids, can also serve as an efficient conformation probe for HTG DNA and discriminate the DNA G-quadruplex from the RNA counterpart.

AChR AMPK BACE Beta-Secretase Cholinesterase (ChE)ERK MEK

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SBI-0206965

SBI0206965

T21281884220-36-3

SBI-0206965 is a potent, selective, and cell-permeable autophagy kinase ULK1 inhibitor with an IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.

AMPK Apoptosis Autophagy

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NMac1

Nm23 activator 1

T709571332290-68-2

NMac1 (Nm23 activator 1) is a natural compound, cassumunene, derived from Zingiber cassumunar Roxb. and traditionally used as an anti-inflammatory agent in East Asia. NMac1 exhibits anti-metastatic potential by directly interacting with the C-terminal of Nm23-H1, activating its NDP kinase (NDPK) enzymatic activity in vitro. NMac1 inhibits breast cancer metastasis in vivo.

AMPK ERK mTOR Others OXPHOS Ras ROS

$330

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GSK-1070916

GSK-1070916A, GSK1070916

T6129942918-07-2

GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex. Phase 1.

AMPK Apoptosis Aurora Kinase FLT Tie-2

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lithospermic acid

T368328831-65-4

lithospermic acid is a potent anti-HIV agent and shows anti-gonadotrophic and anti-thyroidal effects.

AMPK Apoptosis HIV Protease NO Synthase Nrf2 Xanthine Oxidase

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Levocarnitine propionate

ST-261, ST261, ST 261, Propionyl-L-carnitine, L-Propionylcarnitine

T1182L20064-19-1

Levocarnitine propionate (L-Propionylcarnitine) is a propionyl-coenzyme A (Pro-CoA) derivative with anti-ischemic effects and high affinity for muscle L-carnitine transferase. Levocarnitine propionate enhances substrate oxidation and mitochondrial respiration in the heart of diabetic rats, reduces gastric ulcer area, induces mucosal recovery, and can be used to study acute respiratory distress syndrome and chronic gastric ulcers in Alzheimer's disease.

Akt AMPK Apoptosis Bcl-2 Family Endogenous Metabolite NF-κB NO Synthase Src Survivin

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XMD-17-51

XMD17-51

T224601628614-50-5

XMD-17-51 has DCLK1 kinase inhibitory activity, inhibits DCLK1 and cell proliferation, and can be used in lung cancer research.

AMPK CDK Others Serine Protease

$293

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BAY-3827

T733502377576-35-5

BAY-3827 is a potent and selective AMPK inhibitor with potential antitumor activity, demonstrating antiproliferative effects in an androgen-dependent prostate cancer model and inhibiting the phosphorylation of acetyl CoA carboxylase 1 (ACC-1).

Acyltransferase AMPK

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