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AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.

  • Doxorubicin hydrochloride
    T102025316-40-9
    Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). Doxorubicin hydrochloride exhibits cytotoxicity and antitumor activity. Doxorubicin hydrochloride reduces the phosphorylation of AMPK and its downstream target protein acetyl coenzyme A carboxylase, and induces apoptosis and autophagy.
    • $34
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  • Adenosine monophosphate
    T213361-19-8
    Adenosine monophosphate (AMP) is a purine ribonucleoside 5'-monophosphates and a key cellular metabolite in signal transduction and regulation of energy homeostasis.It has a role as an EC 3.1.3.11 (fructose-bisphosphatase) inhibitor, an EC 3.1.3.1 (alkaline phosphatase) inhibitor and an adenosine A1 receptor agonist.
    • $33
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  • AICAR
    T14772627-69-2
    AICAR (NSC105823) is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.
    • $30
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  • Sophocarpine monohydrate
    T2746145572-44-7
    Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
    • $50
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  • Nootkatone
    T3S01954674-50-4
    1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent obesity and improve physical performance through AMPK activation in skeletal muscle and liver.
    • $40
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  • [6]-Gingerol
    T340523513-14-6
    [6]-Gingerol ((S)-(+)-[6]Gingerol), an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bowel, among other tissues.
    • $120
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  • Chitosan oligosaccharide
    T10789148411-57-8
    Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. It has the ability to activate AMPK and simultaneously inhibit inflammatory signaling pathways, including NF-κB and MAPK.
    • $48
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  • Danthron
    T0800117-10-2
    Danthron (Antrapurol) is a natural product, regulates glucose, and lipid metabolism by activating AMPK.
    • $35
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  • MRT67307 HCl (1190378-57-4(free base))
    T5162
    MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).
    • $37
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  • N,N-Didesethyl Sunitinib Hydrochloride
    T60128873077-70-4
    N,N-Didesethyl Sunitinib Hydrochloride is a potent AMPK inhibitor with IC50 of 393 nM and 141 nM for AMPKα1 and AMPK2,respectively.
    • $195
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  • MOTS-c(Human) Acetate(1627580-64-6 free)
    TP2312
    MOTS-c(Human) Acetate is a mitochondrial-derived peptide. MOTS-c(human) acetate induces the accumulation of AMP analog AICAR, increases activation of AMPK and expression of its downstream GLUT4. MOTS-c(human) acetate induces glucose uptake and improves insulin sensitivity. MOTS-c(human) acetate has implications in the regulation of obesity, diabetes, exercise, and longevity.
    • $90
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  • AMPK activator 2 hydrochloride( 2410961-69-0 Free base)
    T60675L
    AMPK activator 2 hydrochloride is a fluoroguanidine-containing derivative that up-regulates the AMPK signaling pathway and down-regulates mTOR/4EBP1/p70S6K.AMPK activator 2 hydrochloride inhibits the proliferation and migration of human cancer cell lines (UMUC3, T24, A549).
    • $80
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  • Annaosanchun
    T196594725-51-3
    Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).
    • $39
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  • DK419
    T151372102672-22-8In house
    DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin.It also induces production of pAMPK.
    • $79
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  • AMPK activator 12
    T78791431920-24-0In house
    AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein in human hepatocytes, which can be used for cancer research.
    • $52 TargetMol
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  • HTH-01-015
    T23741613724-42-7In house
    HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).
    • $37
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  • AMPK activator 4
    T622382493239-46-4In house
    AMPK activator 4 is a potent and selective AMPK activator that does not inhibit mitochondrial complex I. AMPK activator 4 selectively activates AMPK in muscle tissue and dose-dependently improves glucose tolerance in normal mice, significantly reduces fasting glucose levels and improves insulin resistance in db db diabetic mice.AMPK activator 4 has hypoglycemic effects. activator 4 has hypoglycemic effects.
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  • AMAROGENTIN
    T549721018-84-8
    Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive therapeutic role during liver carcinogenesis through modulation of cell cycle and apoptosis
    • $33
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  • A-769662
    T2468844499-71-4
    A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).
    • $33
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  • Doxorubicin
    T145623214-92-8
    Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.
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  • Phillyrin
    T2854487-41-2
    Phillyrin (Forsythin) is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1 AMPK activation. Phillyrin(Forsythin) may be a new preventive agent of acute lung injury in the clinical setting, it potentially contributes to the suppression of the activation of MAPK and NF-κB pathways, it also has protective effects on H2O2-induced oxidative stress and apoptosis in PC12 cells.
    • $39
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  • Dorsomorphin dihydrochloride
    T61461219168-18-9
    Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on structurally related kinases.
    • $30
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  • Metformin hydrochloride
    T07401115-70-4
    Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) , a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. It inhibits the proliferation of a variety of Y cells including colon, prostate, and etc.
    • $33
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  • ARN-3236
    T59931613710-01-2
    ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nM respectively). ARN-3236 Has anti-cancer activity.
    • $55
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  • Adenosine 5'-monophosphate monohydrate
    T0853L18422-05-4
    Adenosine 5'-monophosphate monohydrate (5'-AMP) , also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucleoside adenosine. Adenosine 5'-monophosphate monohydrate consists of a phosphate group, the sugar ribose, and the nucleobase adenine. As a substituent it takes the form of the prefix adenylyl-.
    • $48
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  • Platycodin D
    T388958479-68-8
    Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 12-O-tetradecanoyl phorbol 13-acetate (TPA). Platycodin D and D3 are useful as expectorant agents in the treatment of various airway diseases, they can increase mucin release from rat and hamster tracheal surface epithelial cell culture and also from intact rat trachea upon nebulization.
    • $52
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  • Ginkgolide K
    T8200153355-70-5
    Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signalling pathway. It possesses neuroprotective activity.
    • $80
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  • GSK-690693
    T6285937174-76-0
    GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
    • $41
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  • STO-609
    T354652029-86-4
    STO-609 is a specific and cell-permeable inhibitor of the Ca2+ calmodulin-dependent protein kinase kinase (CaM-KK) for recombinant CaM-KKα KKβ (Ki: 80 15 ng mL).
    • $35
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  • Dorsomorphin
    T1977866405-64-3
    Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive. Dorsomorphin inhibits the BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin induces autophagy, and possesses antitumor activity.
    • $48
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  • Metformin
    T8526657-24-9
    Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is commonly used in type 2 diabetes research.
    • $39
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  • Icariside E4
    TN5431126253-42-7
    Icariside E4 is a natural compound derived from Ulmus minor that acts via AMPK phosphorylation and inhibition of MID1IP2 hypolipidation in HepG1 cells.Icariside E4 has anti-injurious, antioxidant, anti-Alzheimer's and anti-inflammatory effects and inhibits SREBP-1c, liver X receptor-α (LXR) and FASN in Icariside E4 is an effective candidate for the treatment of fatty liver disease and has hypolipidemic potential in HepG1 cells.
    • $1,620
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  • Ganodermanondiol
    TN1670107900-76-5
    Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK.
    • $138
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  • AMPK activator 13
    T83127
    AMPK Activator 13 is a potent activator of the AMPK pathway, effectively inhibiting mitotic clonal expansion in 3T3-L1 cells and enhancing mitochondrial oxygen consumption rates. This compound is utilized in the study of obesity [1].
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  • Kazinol B
    T2023299624-27-8
    Kazinol B is an inhibitor of nitric oxide (NO) production, an isopentenylated flavan with a dimethylpyran ring.Kazinol B improves insulin sensitivity by activating the insulin-Akt signalling pathway and AMPK, which enhances glucose uptake.Kazinol B stimulates gene expression and secretion of adiponectin and can be used to study diabetes.
    • $1,760
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  • Pinusolide
    TL001431685-80-0
    Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to treat neurodegenerative diseases. Pinusolide attenuates blockade of insulin signaling by enhancing IRS-1 tyrosine phosphorylation by the activating the AMPK pathway, indicates the targeting of AMPK represents a new therapeutic strategy for hyperglycemia-induced insulin resistance and type 2 diabetes.
    • $310
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  • AMPK-α1β1γ1 activator 1
    T831251943510-86-8
    AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1 isoforms of human AMPK with an EC50 of 38.1 nM through direct binding to the human AMPK α1β1γ1 isoform. It is utilized in diabetic nephropathy research [1].
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  • RSVA405
    T8476140405-36-3
    RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor
    • $32
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  • HTH-02-006
    T82165
    HTH-02-006, a NUAK2 inhibitor (IC50 = 126 nM), decreases phosphorylated MYPT1 levels in HuCCT-1 cells and inhibits YAP-driven cell proliferation, hepatomegaly, and tumorigenesis. Additionally, it possesses an antifibrotic protective effect [1] [2].
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  • 3α-Hydroxymogrol
    T101051343402-73-2
    3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle. It is a potent AMPK activator and enhances AMPK phosphorylation.
    • $237
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  • Shizukaol D
    TN5013142279-42-3
    Shizukaol D exerts a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner by modulating wnt signalling pathway. Shizukaol D may be used to treat metabolic syndrome, it induces mitochondrial dysfunction by depolarizing the mitochondrial membrane and suppressing energy production, which may result in AMPK activation.
    • $820
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  • Kazinol A
    TN438299624-28-9
    Kazinol A shows strong inhibition of arachidonic acid (AA)-induced platelet aggregation. It also exhibits potent inhibition with IC50 values ranging 0.6-164 M against XOD. Kazinol A may be a candidate for the development of effective anti-cancer drug on h
    • $370
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  • Ligupurpuroside C
    TN18701194056-33-1
    Ligupurpuroside C can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L.
    • $550
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  • HL271
    T115701422365-52-3
    HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.
    • $1,520
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  • Saponarin
    TN217920310-89-8
    Saponarin (Petrocomoside) shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.
    • $72
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  • Chikusetsusaponin IVa
    T386351415-02-2
    Chikusetsusaponin IVa (Calenduloside F) is a novel AMPK activator, can induce insulin secretion from βTC3 cells via GPR4 mediated calcium and PKC pathways, may be developed into a new potential for therapeutic agent used in T2DM patients.
    • $68
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  • YM-53601 free base
    T13371182959-28-0
    YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.
    • $1,520
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  • EX229
    TQ00281219739-36-2
    EX229 (C991) is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.
    • $31
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  • WH-4-025
    T92191876463-35-2
    WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.
    • $34
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  • Flufenamic acid
    T0858530-78-9
    Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically.
    • $33
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