Home Tools

Ladostigil hemitartrate

Catalog No. T39513 CAS 209394-46-7

Synonyms: TV-3326 hemitartrate, Ladostigil hemitartrate

Ladostigil hemitartrate (TV-3326) is a compound that acts as a dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO). It has IC50 values of 37.1 μM for MAO-B and 31.8 μM for AChE. In addition, Ladostigil hemitartrate possesses neuroprotective, antioxidant, and anti-inflammatory properties. It is commonly used in research relating to depression and Alzheimer's disease.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ladostigil hemitartrate Chemical Structure

Ladostigil hemitartrate, CAS 209394-46-7

Pack Size	Availability	Price/USD	Quantity
2 mg	5 days	$ 198.00
5 mg	5 days	$ 386.00

Bulk Inquiry

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ladostigil hemitartrate (TV-3326) is a compound that acts as a dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO). It has IC50 values of 37.1 μM for MAO-B and 31.8 μM for AChE. In addition, Ladostigil hemitartrate possesses neuroprotective, antioxidant, and anti-inflammatory properties. It is commonly used in research relating to depression and Alzheimer's disease.
Targets&IC50	MAO-B:37.1 nM (IC50), AChE:31.8 nM (IC50)
In vitro	Ladostigil hemitartrate (1-10 μM) demonstrates significant neuroprotective properties by preventing the decrease of mitochondrial membrane potential (ψ), attenuating apoptotic cascades, and inhibiting ROS production triggered by oxidative stress (OS) insults[2]. Additionally, it inhibits caspase-3 activation, upregulates Bcl-2, and decreases Bad and Bax gene and protein expression in human neuroblastoma SK-N-SH cells[2].
In vivo	Ladostigil hemitartrate, administered orally at 17 mg/kg daily for six weeks, effectively eliminates hyperanxiety and depressive-like behaviors in Sprague-Dawley rats, observed through the elevated plus maze (EPM) and forced swim tests (FST) from puberty into adulthood. This treatment regimen notably inhibited brain monoamine oxidase A and B (MAO-A and B) activity by over 60% and mitigated the heightened anxiety and depressive symptoms in both male and female rats prenatally stressed (PS). Additionally, a single oral dose of Ladostigil hemitartrate at 50 μmol/kg was sufficient to reverse episodic memory loss in the object recognition test in rats, showcasing its potential therapeutic effects on memory impairments.

Synonyms	TV-3326 hemitartrate, Ladostigil hemitartrate
Molecular Weight	422.434
Formula	C20H26N2O8
CAS No.	209394-46-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Denya I, et, al. Design, synthesis and evaluation of indole derivatives as multifunctional agents against Alzheimer's disease. Medchemcomm. 2018 Jan 16;9(2):357-370. 2. Weinreb O, et, al. Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012 Apr;13(4):483-94. 3. Weinstock M, et, al. Ladostigil, a novel multifunctional drug for the treatment of dementia co-morbid with depression. J Neural Transm Suppl. 2006;(70):443-6. 4. Poltyrev T, et, al. Effect of chronic treatment with ladostigil (TV-3326) on anxiogenic and depressive-like behaviour and on activity of the hypothalamic-pituitary-adrenal axis in male and female prenatally stressed rats. Psychopharmacology (Berl). 2005 Aug;181(1):118-25.

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ladostigil hemitartrate 209394-46-7 TV 3326 Hemitartrate Ladostigil Hemitartrate TV-3326 Hemitartrate TV-3326 hemitartrate TV3326 TV 3326 TV3326 Hemitartrate Ladostigil TV-3326 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.