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Anti-Caspase-3 Antibody (5I480)
(Synonyms: Yama, SCA-1, CPP32B, CPP32, apopain) Copy Product Info
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Synonyms: Yama, SCA-1, CPP32B, CPP32, apopain
Catalog No. TMAH-00142 Copy Product Info
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Anti-Caspase-3 Antibody (5I480) is an antibody targeting Caspase-3. Anti-Caspase-3 Antibody (5I480) can be used in ELISA,IHC,WB.
Anti-Caspase-3 Antibody
(5I480)
(5I480)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $207 | 7-10 days | 7-10 days | |
| 100 μL | $349 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
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| Description | Anti-Caspase-3 Antibody (5I480) is an antibody targeting Caspase-3. Anti-Caspase-3 Antibody (5I480) can be used in ELISA,IHC,WB. |
| Synonyms | Yama, SCA-1, CPP32B, CPP32, apopain |
| Ig Type | Rabbit IgG |
| Clone | 5I480 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB:1:500-1:5000; IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. |
| Tissue Specificity | Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress. Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human pro Caspase 3 |
| Antigen Species | Human |
| Gene Name | CASP3 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Cancer, Cell biology, Metabolism |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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