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DDX3-IN-1

Name: DDX3-IN-1
Brand: TargetMol
SKU: T10986
Price: 199 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10986Cas No. 1919828-83-3

DDX3-IN-1 (Compound 16f) is a DDX3 (DEAD box polypeptide 3) inhibitor (IC50 >100 μM) with antiviral activity against HIV and HCV, with EC50 values of >50 and >36 μM, respectively.

DDX3-IN-1

😃Good

Catalog No. T10986Cas No. 1919828-83-3

DDX3-IN-1 (Compound 16f) is a DDX3 (DEAD box polypeptide 3) inhibitor (IC50 >100 μM) with antiviral activity against HIV and HCV, with EC50 values of >50 and >36 μM, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$199	-	In Stock
5 mg	$296	Inquiry	Inquiry

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	DDX3-IN-1 (Compound 16f) is a DDX3 (DEAD box polypeptide 3) inhibitor (IC50 >100 μM) with antiviral activity against HIV and HCV, with EC50 values of >50 and >36 μM, respectively.
In vitro	DDX3-IN-1 was found to be cytotoxic to HIV NL4-3 infected PBMCs and HCV replicon infected LucUbiNeo-ET cells with CC50 values of 50 μM and 36 μM, respectively.[1]

Chemical Properties

Molecular Weight	307.35
Formula	C₁₇H₁₇N₅O
Cas No.	1919828-83-3
Smiles	O=C(NC1=CC=C(C=C1)N2N=NC(=C2)C)NC=3C=CC=CC3C
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (325.36 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (13.01 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2536 mL	16.2681 mL	32.5362 mL	162.6810 mL
5 mM	0.6507 mL	3.2536 mL	6.5072 mL	32.5362 mL
10 mM	0.3254 mL	1.6268 mL	3.2536 mL	16.2681 mL
20 mM	0.1627 mL	0.8134 mL	1.6268 mL	8.1340 mL
50 mM	0.0651 mL	0.3254 mL	0.6507 mL	3.2536 mL
100 mM	0.0325 mL	0.1627 mL	0.3254 mL	1.6268 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc