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6-Hydroxynicotinic acid

Name: 6-Hydroxynicotinic acid
Brand: TargetMol
SKU: T4816
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4816Cas No. 5006-66-6

Alias 6-Hydroxypyridine-3-carboxylic acid, 2-Hydroxy-5-pyridinecarboxylic acid

6-Hydroxynicotinic acid (6-Hydroxypyridine-3-carboxylic acid) is exploited in the use of NMR spectroscopy or gas chromatography--mass spectrometry for the diagnosis of Pseudomonas aeruginosa in urinary tract infection. Among the common bacteria causing urinary infection, only P. aeruginosa produces 6-hydroxynicotinic acid from nicotinic acid.

6-Hydroxynicotinic acid

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Purity: 98.98%

Catalog No. T4816Alias 6-Hydroxypyridine-3-carboxylic acid, 2-Hydroxy-5-pyridinecarboxylic acidCas No. 5006-66-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.98%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

6-Hydroxynicotinic acid AI Summary

6-Hydroxynicotinic acid has inhibitory activity against the dihydroorotate dehydrogenase 1A (1A DHOD) family from Lactococcus lactis at a concentration of 1 µM, demonstrating an activity level of 94.0%. Additionally, the compound exhibits significant bioactivity in blocking the entry of the Ebola virus, with an AC50 value of 0.5623 µM in one assay and 562.3 nM in another assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	6-Hydroxynicotinic acid (6-Hydroxypyridine-3-carboxylic acid) is exploited in the use of NMR spectroscopy or gas chromatography--mass spectrometry for the diagnosis of Pseudomonas aeruginosa in urinary tract infection. Among the common bacteria causing urinary infection, only P. aeruginosa produces 6-hydroxynicotinic acid from nicotinic acid.
Synonyms	6-Hydroxypyridine-3-carboxylic acid, 2-Hydroxy-5-pyridinecarboxylic acid

Chemical Properties

Molecular Weight	139.11
Formula	C₆H₅NO₃
Cas No.	5006-66-6
Smiles	OC(=O)C1=CC=C(O)N=C1
Relative Density.	1.451 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (359.43 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (7.19 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.1886 mL	35.9428 mL	71.8856 mL	359.4278 mL
5 mM	1.4377 mL	7.1886 mL	14.3771 mL	71.8856 mL
10 mM	0.7189 mL	3.5943 mL	7.1886 mL	35.9428 mL
20 mM	0.3594 mL	1.7971 mL	3.5943 mL	17.9714 mL
50 mM	0.1438 mL	0.7189 mL	1.4377 mL	7.1886 mL
100 mM	0.0719 mL	0.3594 mL	0.7189 mL	3.5943 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc