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Evinacumab
🥰Excellent
Catalog No. T77492Cas No. 1446419-85-7
Alias REGN1500, REGN 1500
Evinacumab (REGN1500) is a humanized monoclonal antibody targeting ANGPTL3. It is useful for studying cardiovascular diseases.
Evinacumab
Evinacumab
🥰Excellent
Purity: 100% (SEC-HPLC)
Catalog No. T77492Alias REGN1500, REGN 1500Cas No. 1446419-85-7
Evinacumab (REGN1500) is a humanized monoclonal antibody targeting ANGPTL3. It is useful for studying cardiovascular diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $372 | In Stock | |
| 5 mg | $993 | In Stock | |
| 10 mg | $1,330 | In Stock | |
| 25 mg | $1,980 | In Stock | |
| 50 mg | $2,680 | In Stock |
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Concentration:5.12 mg/mL
Purity:100% (SEC-HPLC)
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Product Introduction
Bioactivity
Chemical Properties
| Description | Evinacumab (REGN1500) is a humanized monoclonal antibody targeting ANGPTL3. It is useful for studying cardiovascular diseases. |
| In vitro | Evinacumab has similar affinity for ANGPTL3 in human, mouse, rat and monkey with KD = 0.26-1.28 nM. [1] |
| In vivo | Evinacumab (10 mg/kg intrperitoneally administered once weekly for 8 weeks) reduced serum TGs in C57Bl/6 mice with normal lipemia. After Evinacumab treatment, heparin LPL activity increased 1.8 times in C57Bl/6 mice and 2.5 times in db/db mice. Evinacumab (3 mg/kg or 10 mg/kg) reduced blood lipids in cynomolgus monkeys. [1] |
| Synonyms | REGN1500, REGN 1500 |
| Molecular Weight | 145.5 kDa |
| Cas No. | 1446419-85-7 |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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