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SGC-AAK1-1

Name: SGC-AAK1-1
Brand: TargetMol
SKU: T12885
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12885Cas No. 2247894-32-0

SGC-AAK1-1, a potent and selective inhibitor of AAK1 (AP2-associated kinase 1), has an IC50 of 270 nM and a Ki of 9 nM, and serves as a chemical probe.

SGC-AAK1-1

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Purity: 99.68%

Catalog No. T12885Cas No. 2247894-32-0

SGC-AAK1-1, a potent and selective inhibitor of AAK1 (AP2-associated kinase 1), has an IC50 of 270 nM and a Ki of 9 nM, and serves as a chemical probe.

Pack Size	Price	Availability
5 mg	$38	In Stock
10 mg	$73	In Stock
25 mg	$148	In Stock
50 mg	$290	In Stock
100 mg	$415	In Stock
200 mg	$596	In Stock
1 mL x 10 mM (in DMSO)	$42	In Stock

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Purity:99.68%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	SGC-AAK1-1, a potent and selective inhibitor of AAK1 (AP2-associated kinase 1), has an IC50 of 270 nM and a Ki of 9 nM, and serves as a chemical probe.
Targets&IC50	AAK:9 nM
In vitro	phosphorylation of AP2M1 (T156)significantly reduced by SGC-AAK1-1 (1.25 μM) and activates WNT-driven BAR activity compared in a dose-dependent manner in HT1080 cells. SGC-AAK1-1 blocks AAK1 kinase activity, resulting in increased β-catenin protein stability and β-catenin-dependent transcription.

Chemical Properties

Molecular Weight	427.52
Formula	C₂₁H₂₅N₅O₃S
Cas No.	2247894-32-0
Smiles	CCN(CC)S(=O)(=O)Nc1cccc(c1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1
Relative Density.	1.424 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (93.56 mM), Sonication and heating to 60℃ are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3391 mL	11.6954 mL	23.3907 mL	116.9536 mL
5 mM	0.4678 mL	2.3391 mL	4.6781 mL	23.3907 mL
10 mM	0.2339 mL	1.1695 mL	2.3391 mL	11.6954 mL
20 mM	0.1170 mL	0.5848 mL	1.1695 mL	5.8477 mL
50 mM	0.0468 mL	0.2339 mL	0.4678 mL	2.3391 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc