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Anti-KEAP1 Polyclonal Antibody 2

(Synonyms: KLHL19, kelch like ECH associated protein 1, KEAP-1, INRF2) Copy Product Info
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Synonyms: KLHL19, kelch like ECH associated protein 1, KEAP-1, INRF2

Catalog No. TMAB-01018 Copy Product Info
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Anti-KEAP1 Polyclonal Antibody 2 is a Rabbit antibody targeting KEAP1. Anti-KEAP1 Polyclonal Antibody 2 can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P, WB.
Anti-KEAP1 Polyclonal Antibody 2
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2217-10 days7-10 days
100 μL$3747-10 days7-10 days
200 μL$5277-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-KEAP1 Polyclonal Antibody 2 is a Rabbit antibody targeting KEAP1. Anti-KEAP1 Polyclonal Antibody 2 can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P, WB.
SynonymsKLHL19, kelch like ECH associated protein 1, KEAP-1, INRF2
Ig Type
IgG
Reactivity
Human,Mouse,Rat (predicted:Dog,Pig,Cow,Rabbit)
Application
Recommended Dose
FCM=1 μg/Test; ICC/IF=1:100-500; IF=1:100-500; IHC-Fr=1:100-500; IHC-P=1:100-500; WB=1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus.
Tissue SpecificityBroadly expressed, with highest levels in skeletal muscle.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1 mg/mL
Research BackgroundThis gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008].
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human KEAP1
Antigen Species
Human
Gene Name
KEAP1
Gene ID
Protein Name
Kelch-like ECH-associated protein 1
Uniprot ID
Biology Area
Ubiquitylation
Function
Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Chemical Properties
Molecular WeightTheoretical: 69 kDa. Actual: 69 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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