JH-XI-10-02

Name: JH-XI-10-02
Brand: TargetMol
SKU: T13743
Rating: 4.5 (1 reviews)

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Catalog No. T13743Cas No. 2209085-22-1

JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC.

JH-XI-10-02

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Catalog No. T13743Cas No. 2209085-22-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$1,980	35 days	35 days

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Product Introduction

Bioactivity

Description	JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC.
Targets&IC50	Cereblon:, CDK8:159 nM

Chemical Properties

Molecular Weight	920.161
Formula	C₅₃H₆₉N₅O₉
Cas No.	2209085-22-1
Smiles	[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])C[C@H](CC[C@]4(C)[C@@]3([H])CC[C@]12C)N(C)C(=O)CCOCCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)c1ccc2ccncc2c1
Relative Density.	1.28 g/cm3 (Predicted)

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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