IL-17A Protein, Human, Recombinant (CHO)

Name: IL-17A Protein, Human, Recombinant (CHO)
Brand: TargetMol
SKU: TMPY-07091
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: ILA17, IL-17A, IL-17, IL17, CTLA-8, CTLA8) Copy Product Info

Synonyms: ILA17, IL-17A, IL-17, IL17, CTLA-8, CTLA8

Catalog No. TMPY-07091 Copy Product Info

IL-17A Protein, Human, Recombinant (CHO) is expressed in CHO Stable Cells. The accession number is Q16552.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$88	-	In Stock
10 µg	$136	7-10 days	7-10 days
20 µg	$219	7-10 days	7-10 days
50 µg	$417	7-10 days	7-10 days
100 µg	$790	7-10 days	7-10 days
200 µg	$1,200	7-10 days	7-10 days
500 µg	$2,580	7-10 days	7-10 days
1 mg	$5,280	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:≥ 85 % as determined by SDS-PAGE, ≥ 90 % as determined by SEC-HPLC, ≥ 90% as determined by SEC-MALS(Routinely tested).

Appearance:Lyophilized powder

Color:White

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COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	1. Measured by its binding ability in a functional ELISA. Immobilized IL-17A Protein, Human, Recombinant (CHO) (Cat#TMPY-07091) at 10 μg/ml (100 μl/well) can bind human IL17Ra, The EC50of human IL17Ra is 20.0-48.0 ng/mL. 2. Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells in the presense of 20 ng/mL TNFα. The ED50 for this effect is 0.2-1 ng/mL. 3. Ixekizumab captured on Protein A chip can bind IL-17A Protein, Human, Recombinant (CHO) (Cat#TMPY-07091) with an affinity constant of 9.13 pM as determined in an SPR assay (Biacore 8K) (Routinely tested)
Description	IL-17A Protein, Human, Recombinant (CHO) is expressed in CHO Stable Cells. The accession number is Q16552.
Species	Human
Expression System	CHO Cells
Tag	Tag Free
Accession Number	Q16552
Construction	A DNA sequence encoding the human IL17A (Q16552) (Met1-Ala155) was expressed.
Protein Purity	≥ 85% as determined by SDS-PAGE, ≥ 90% as determined by SEC-HPLC, ≥ 90% as determined by SEC-MALS(Routinely tested).
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstituted with sterile deionized water to 0.1 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	ILA17, IL-17A, IL-17, IL17, CTLA-8, CTLA8
Research Background	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

15.1 kDa (predicted); 16, 19, and 20 kDa (reducing contition, due to glycosylation); 31.6 kDa (SEC-MALS)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.