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RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His)
(Synonyms: tumor necrosis factor receptor superfamily member 11A, TRANCER, TRANCE R, TNFRSF11A, receptor activator of nuclear factor-κ B, receptor activator of nuclear factor-kappa B, Receptor activator of NF-KB, RANK1, PDB2, OPTB7, OFE, ODFROSTS, ODFR, FEO, CD265 antigen, CD265) Copy Product InfoSynonyms: tumor necrosis factor receptor superfamily member 11A, TRANCER, TRANCE R, TNFRSF11A, receptor activator of nuclear factor-κ B, receptor activator of nuclear factor-kappa B, Receptor activator of NF-KB, RANK1, PDB2, OPTB7, OFE, ODFROSTS, ODFR, FEO, CD265 antigen, CD265
Catalog No. TMPJ-00349 Copy Product Info
Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It plays a vital role in bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. RANK is constitutively expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoclast, mammary gland epithelial cells, prostate, vascular cell, and pancreas.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $68 | 7-10 days | 7-10 days | |
| 10 μg | $110 | 7-10 days | 7-10 days | |
| 20 μg | $169 | 7-10 days | 7-10 days | |
| 50 μg | $310 | 7-10 days | 7-10 days | |
| 100 μg | $475 | 7-10 days | 7-10 days | |
| 200 μg | $732 | 7-10 days | 7-10 days | |
| 500 μg | $1,300 | 7-10 days | 7-10 days | |
| 1 mg | $1,980 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Loaded Human RANK-His on HIS1K Biosensor, can bind Human RANK L with an affinity constant of <1 pM as determined in BLI assay. (Regularly tested) |
| Description | Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It plays a vital role in bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. RANK is constitutively expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoclast, mammary gland epithelial cells, prostate, vascular cell, and pancreas. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-6xHis |
| Accession Number | Q9Y6Q6 |
| Amino Acid | Ile30-Pro212 |
| Construction | Ile30-Pro212 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | tumor necrosis factor receptor superfamily member 11A, TRANCER, TRANCE R, TNFRSF11A, receptor activator of nuclear factor-κ B, receptor activator of nuclear factor-kappa B, Receptor activator of NF-KB, RANK1, PDB2, OPTB7, OFE, ODFROSTS, ODFR, FEO, CD265 antigen, CD265 |
| Research Background |
| Molecular Weight | 25-30 KDa (reducing condition) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His) chemical structure | RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His) molecular weight
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