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TrkB activator-1 D3
Catalog No. TMIT-0013 Copy Product Info
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Trk Bactivator-1 D3 is a specific, orally active activator of tropomyosin receptor kinase B (TrkB) that can penetrate the blood-brain barrier. By activating the brain-derived neurotrophic factor (BDNF)-TrkB-cAMP response element-binding protein (CREB) signaling pathway, TrkBactivator-1 exhibits potent antidepressant effects and enhances neural plasticity. It is applicable for research into neurological disorders such as depression.
TrkB activator-1 D3
Copy Product Info🥰Excellent
Catalog No. TMIT-0013
Trk Bactivator-1 D3 is a specific, orally active activator of tropomyosin receptor kinase B (TrkB) that can penetrate the blood-brain barrier. By activating the brain-derived neurotrophic factor (BDNF)-TrkB-cAMP response element-binding protein (CREB) signaling pathway, TrkBactivator-1 exhibits potent antidepressant effects and enhances neural plasticity. It is applicable for research into neurological disorders such as depression.
TrkB activator-1 D3
Cas No. 3087336-56-6
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | Trk Bactivator-1 D3 is a specific, orally active activator of tropomyosin receptor kinase B (TrkB) that can penetrate the blood-brain barrier. By activating the brain-derived neurotrophic factor (BDNF)-TrkB-cAMP response element-binding protein (CREB) signaling pathway, TrkBactivator-1 exhibits potent antidepressant effects and enhances neural plasticity. It is applicable for research into neurological disorders such as depression. |
| In vitro | TrkB activator-1 (Compound B11), when applied at concentrations of 3-100 μM for 24 hours, can enhance the total length, number, and intersection count of neurites in hippocampal neurons. Additionally, at concentrations of 1-100 μM for periods ranging from 0.25 to 2 hours, it upregulates BDNF in these neurons in a dose-dependent manner. Furthermore, at 3-100 μM for 15 minutes, it increases the levels of p-TrkB, p-PLCγ, PKA, and p-CREB in hippocampal neurons. |
| In vivo | TrkB activator-1 (Compound B11) exhibits a rapid-onset antidepressant effect in mice subjected to a chronic unpredictable mild stress-induced depression model when administered orally in a single dose at 7.5-100 mg/kg. |
| Molecular Weight | 268.33 |
| Formula | C13H19N3O3 |
| Cas No. | 3087336-56-6 |
| Smiles | C(N[C@@H]([C@H](C)C)C1=NC=CO1)(=O)[C@@H]2N(C(C([2H])([2H])[2H])=O)CC2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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