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ERX-41

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Catalog No. T78528Cas No. 2440087-54-5

ERX-41 is an orally active, stereospecific small molecule that targets lysosomal acid lipase A (LIPA). It induces endoplasmic reticulum (ER) stress, leading to cell death independently of its LIPA activity yet reliant on its ER localization, suggesting a role in targeted solid tumor therapies [1].

ERX-41

ERX-41

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Catalog No. T78528Cas No. 2440087-54-5
ERX-41 is an orally active, stereospecific small molecule that targets lysosomal acid lipase A (LIPA). It induces endoplasmic reticulum (ER) stress, leading to cell death independently of its LIPA activity yet reliant on its ER localization, suggesting a role in targeted solid tumor therapies [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$31635 days35 days
5 mg$1,38035 days35 days
10 mg$2,66035 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
ERX-41 is an orally active, stereospecific small molecule that targets lysosomal acid lipase A (LIPA). It induces endoplasmic reticulum (ER) stress, leading to cell death independently of its LIPA activity yet reliant on its ER localization, suggesting a role in targeted solid tumor therapies [1].
In vitro
ERX-41 (1 μM; 0-30 h) induces cell death in MDA-MB-231 cells without significantly affecting normal human mammary epithelial cells (HMECs) [1]. Additionally, ERX-41 (1 μM; 2 h, 4 h) causes rapid endoplasmic reticulum expansion and peripheral endoplasmic reticulum disarray within 4 hours and 2 hours, respectively [1]. Moreover, ERX-41 (1 μM; 0.5-4 h) activates the unfolded protein response (UPR) pathway by promoting p-PERK and p-eIF2-α [1].
In vivo
ERX-41 (10 mg/kg; oral or intraperitoneal injection; single dose) is detectable within the tumor 1.5 hours post-administration, regardless of the administration route [1]. A single oral dose of ERX-41 at 10 mg/kg significantly inhibits tumor progression in both the MDA-MB-231 and D2A1 xenograft mouse models without affecting mouse body weight [1].
Chemical Properties
Molecular Weight704.81
FormulaC38H48N4O9
Cas No.2440087-54-5
SmilesN(C(=O)C1=CC(OCCO)=C(N(=O)=O)C=C1)C2=C(OCC(C)C)C=C(C(NC3=C(OCC(C)C)C=C(C(N[C@H]4CC[C@H](C)CC4)=O)C=C3)=O)C=C2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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