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Kira8

Name: Kira8
Brand: TargetMol
SKU: T11762L
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11762LCas No. 1630086-20-2

Alias AMG-18

Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.

Kira8

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Purity: 98.07%

Catalog No. T11762LAlias AMG-18Cas No. 1630086-20-2

Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.

Pack Size	Price	Availability
1 mg	$89	In Stock
5 mg	$213	In Stock
10 mg	$322	In Stock
25 mg	$597	In Stock
50 mg	$852	In Stock
100 mg	$1,170	In Stock
1 mL x 10 mM (in DMSO)	$283	In Stock

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Purity:98.07%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.
Targets&IC50	IRE1α:5.9 nM(IRE1α RNase)
In vitro	Kira8 more effectively causes IRE1α-driven apoptosis in INS-1 cells than KIRA6 and also reverses XBP1 splicing promoted by GNF-2. Kira8 blocks IRE1α oligomerization and effectively inhibits IRE1α RNase activity against XBP1 and Ins2 RNAs.
In vivo	One week of treatment of pre-diabetic NODs mice with Kira8 (50 mg/kg; i.p.; once a day) causes obvious reductions in islet XBP1 splicing and TXNIP mRNAs. It also preserves Ins1/Ins2, BiP, and MANF mRNAs. Male Ins2+/Akita mice are injected i.p. with KIRA8 (50 mg/kg; daily; for 35 days), obviously reduction of hyperglycemia becomes apparent over several weeks.
Synonyms	AMG-18

Chemical Properties

Molecular Weight	601.12
Formula	C₃₁H₂₉ClN₆O₃S
Cas No.	1630086-20-2
Smiles	Cc1ccc2c(NS(=O)(=O)c3ccccc3Cl)cccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CCCNC2)n1
Relative Density.	1.383 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (108.13 mM), Sonication is recommended.

H2O: insoluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6636 mL	8.3178 mL	16.6356 mL	83.1781 mL
5 mM	0.3327 mL	1.6636 mL	3.3271 mL	16.6356 mL
10 mM	0.1664 mL	0.8318 mL	1.6636 mL	8.3178 mL
20 mM	0.0832 mL	0.4159 mL	0.8318 mL	4.1589 mL
50 mM	0.0333 mL	0.1664 mL	0.3327 mL	1.6636 mL
100 mM	0.0166 mL	0.0832 mL	0.1664 mL	0.8318 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc