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CGK733

Name: CGK733
Brand: TargetMol
SKU: T1821
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T1821Cas No. 905973-89-9

Alias CGK 733

CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.

CGK733

🥰Excellent

Purity: 99.67%

Catalog No. T1821Alias CGK 733Cas No. 905973-89-9

CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.

Pack Size	Price	Availability
5 mg	$30	In Stock
10 mg	$51	In Stock
25 mg	$97	In Stock
50 mg	$179	In Stock
100 mg	$355	In Stock
500 mg	$842	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

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Purity:99.67%

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.
In vivo	In senescent cells with halted proliferation, treatment with CGK733 leads to the disappearance of senescence-associated beta-galactosidase (SA-β-gal) activity, enabling the cells to proliferate. In aged MCF-7 cells, 24-hour treatment with CGK733 (30 μM) can induce cell death. Furthermore, in various cancer cells, such as MCF-7 and T47D estrogen receptor (ER) positive breast cancer cells, MDA-MB436 ER-negative breast cancer cells, LnCap precursor cancer cells, and HCT116 colon cancer cells, CGK733 (0.6-40 μM) has the capability to inhibit proliferation.
Synonyms	CGK 733

Chemical Properties

Molecular Weight	555.84
Formula	C₂₃H₁₈Cl₃FN₄O₃S
Cas No.	905973-89-9
Smiles	[O-][N+](=O)c1cc(NC(=S)NC(NC(=O)C(c2ccccc2)c2ccccc2)C(Cl)(Cl)Cl)ccc1F
Relative Density.	1.502 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (179.91 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7991 mL	8.9954 mL	17.9908 mL	89.9539 mL
5 mM	0.3598 mL	1.7991 mL	3.5982 mL	17.9908 mL
10 mM	0.1799 mL	0.8995 mL	1.7991 mL	8.9954 mL
20 mM	0.0900 mL	0.4498 mL	0.8995 mL	4.4977 mL
50 mM	0.0360 mL	0.1799 mL	0.3598 mL	1.7991 mL
100 mM	0.0180 mL	0.0900 mL	0.1799 mL	0.8995 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc