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CGK733

Name: CGK733
Brand: TargetMol
SKU: T1821
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1821Cas No. 905973-89-9

Alias CGK 733

CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.

CGK733

😃Good

Purity: 99.67%

Catalog No. T1821Alias CGK 733Cas No. 905973-89-9

CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$51	In Stock	In Stock
25 mg	$97	In Stock	In Stock
50 mg	$179	In Stock	In Stock
100 mg	$355	In Stock	In Stock
500 mg	$842	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.67%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.
In vivo	In senescent cells with halted proliferation, treatment with CGK733 leads to the disappearance of senescence-associated beta-galactosidase (SA-β-gal) activity, enabling the cells to proliferate. In aged MCF-7 cells, 24-hour treatment with CGK733 (30 μM) can induce cell death. Furthermore, in various cancer cells, such as MCF-7 and T47D estrogen receptor (ER) positive breast cancer cells, MDA-MB436 ER-negative breast cancer cells, LnCap precursor cancer cells, and HCT116 colon cancer cells, CGK733 (0.6-40 μM) has the capability to inhibit proliferation.
Synonyms	CGK 733

Chemical Properties

Molecular Weight	555.84
Formula	C₂₃H₁₈Cl₃FN₄O₃S
Cas No.	905973-89-9
Smiles	[O-][N+](=O)c1cc(NC(=S)NC(NC(=O)C(c2ccccc2)c2ccccc2)C(Cl)(Cl)Cl)ccc1F
Relative Density.	1.502 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (179.91 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7991 mL	8.9954 mL	17.9908 mL	89.9539 mL
5 mM	0.3598 mL	1.7991 mL	3.5982 mL	17.9908 mL
10 mM	0.1799 mL	0.8995 mL	1.7991 mL	8.9954 mL
20 mM	0.0900 mL	0.4498 mL	0.8995 mL	4.4977 mL
50 mM	0.0360 mL	0.1799 mL	0.3598 mL	1.7991 mL
100 mM	0.0180 mL	0.0900 mL	0.1799 mL	0.8995 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc