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TRPA1-IN-2

Name: TRPA1-IN-2
Brand: TargetMol
SKU: T77511
Price: 54 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T77511Cas No. 2415206-22-1

TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 µM.TRPA1-IN-2 has anti-inflammatory activity.

TRPA1-IN-2

🥰Excellent

Purity: 98.05%

Catalog No. T77511Cas No. 2415206-22-1

TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 µM.TRPA1-IN-2 has anti-inflammatory activity.

Pack Size	Price	Availability
1 mg	$54	In Stock
5 mg	$138	In Stock
10 mg	$209	In Stock
25 mg	$355	In Stock
50 mg	$496	In Stock
100 mg	$667	In Stock
200 mg	$896	In Stock
1 mL x 10 mM (in DMSO)	$153	In Stock

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Batch Information

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Purity:98.05%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 µM.TRPA1-IN-2 has anti-inflammatory activity.
Targets&IC50	TRPA1:0.04 μM
In vivo	TRPA1-IN-2 (90 mg/kg, i.p. in mice; 30 mg/kg, i.p. in rats; 100 mg/kg, orally) reduced the total number of white blood cells and eosinophils in BALF, demonstrating anti-inflammatory activity.[1]

Chemical Properties

Molecular Weight	442.48
Formula	C₂₄H₂₅F₃N₄O
Cas No.	2415206-22-1
Smiles	C(=O)(C1(NC2=CC=C(C#N)C=C2)CCCC1)N3CCN(CC3)C4=CC=C(C(F)(F)F)C=C4
Relative Density.	1.32 g/cm3 at 20℃ (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (113 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2600 mL	11.2999 mL	22.5999 mL	112.9995 mL
5 mM	0.4520 mL	2.2600 mL	4.5200 mL	22.5999 mL
10 mM	0.2260 mL	1.1300 mL	2.2600 mL	11.2999 mL
20 mM	0.1130 mL	0.5650 mL	1.1300 mL	5.6500 mL
50 mM	0.0452 mL	0.2260 mL	0.4520 mL	2.2600 mL
100 mM	0.0226 mL	0.1130 mL	0.2260 mL	1.1300 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc