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Anti-Phospho-PTEN (Ser380) Antibody (5A114)
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Catalog No. TMAY-01655
Alias TEP1, PTENgama, PTENbeta, PTEN1, PTEN (p-Ser380), PTEN (p-S380), p-PTEN (Ser380), p-PTEN (S380), Phospho-PTEN (S380), MMAC1, MHAM, GLM2, DEC, CWS1, BZS, 10q23del
Anti-Phospho-PTEN (Ser380) Antibody (5A114) is a Rabbit antibody targeting Phospho-PTEN (Ser380). Anti-Phospho-PTEN (Ser380) Antibody (5A114) can be used in WB.
Anti-Phospho-PTEN (Ser380) Antibody (5A114)
Anti-Phospho-PTEN (Ser380) Antibody (5A114)
😃Good
Catalog No. TMAY-01655Alias TEP1, PTENgama, PTENbeta, PTEN1, PTEN (p-Ser380), PTEN (p-S380), p-PTEN (Ser380), p-PTEN (S380), Phospho-PTEN (S380), MMAC1, MHAM, GLM2, DEC, CWS1, BZS, 10q23del
Anti-Phospho-PTEN (Ser380) Antibody (5A114) is a Rabbit antibody targeting Phospho-PTEN (Ser380). Anti-Phospho-PTEN (Ser380) Antibody (5A114) can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $80 | 7-10 days | |
| 100 μL | $233 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: WB Reactivity: Human |
| Alias | TEP1, PTENgama, PTENbeta, PTEN1, PTEN (p-Ser380), PTEN (p-S380), p-PTEN (Ser380), p-PTEN (S380), Phospho-PTEN (S380), MMAC1, MHAM, GLM2, DEC, CWS1, BZS, 10q23del |
| Ig Type | Rabbit IgG |
| Clone | 5A114 |
| Reactivity | Human;
Species predicted to react based on 100% sequence homology: mouse, rat, cynomolgus |
| Verified Activity | Western blot analysis of extracts from Hela, untreated (line A); treated with λ-phosphatase (line B) using Phospho-PTEN (Ser380) rabbit monoclonal Antibody at 1:1000 dilution. (We are unsure as to the identity of these extra bands.) |
| Application | WB |
| Recommended Dose | WB: 1:500-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with a synthetic phosphopeptide corresponding to residues around Ser380 of the Human Phospho-PTEN. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5 |
| Research Background | PTEN gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translations start codons results in multiple transcript variants encoding different isoforms.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: residues around Ser380 of the Human Phospho-PTEN |
| Antigen Species | Human |
| Biology Area | Phosphatases and Regulators, Tumor Suppressors, Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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