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Folinic Acid Calcium Salt Pentahydrate
🥰Excellent
Catalog No. T0148LCas No. 6035-45-6
Alias Leucovorin calcium salt pentahydrate, Leucovorin Calcium Pentahydrate
Folinic Acid Calcium Salt Pentahydrate (Leucovorin Calcium Pentahydrate), a reduced folic acid, is used in combination with other chemotherapeutics.
Folinic Acid Calcium Salt Pentahydrate
🥰Excellent
Purity: 99.17%
Catalog No. T0148LAlias Leucovorin calcium salt pentahydrate, Leucovorin Calcium PentahydrateCas No. 6035-45-6
Folinic Acid Calcium Salt Pentahydrate (Leucovorin Calcium Pentahydrate), a reduced folic acid, is used in combination with other chemotherapeutics.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 mg | $30 | In Stock | In Stock | |
| 100 mg | $41 | In Stock | In Stock | |
| 500 mg | $80 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.17%
Appearance:Solid
Color:White to Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Folinic Acid Calcium Salt Pentahydrate (Leucovorin Calcium Pentahydrate), a reduced folic acid, is used in combination with other chemotherapeutics. |
| In vitro | Administering either 100 or 200 mg/kg of Leucovorin bi-daily for 4-6 days reduced the concentration of RTX in the liver by 2-4 fold compared to the control group in mice. Post severe weight loss and diarrhea, dosing mice with 200 mg/kg of Leucovorin twice daily for 5-7 days prevented further weight decline and initiated early recovery. Concurrent use of Leucovorin/5-FU with a gastric and colorectal cancer vaccine (200 mg/ml) enhanced the therapeutic effect on the growth of DHDK12 tumors in vivo. |
| In vivo | In both tumor and normal tissues, Leucovorin acts as a reduced folate cofactor, competitively transporting and promoting polyglutamation with RTX, thereby serving as a potential rescue agent. In CCRF-CEM cells, Leucovorin enhances the toxicity of trimethoprim/fluorouracil but does not increase the toxicity of methotrexate/fluorouracil. It also enhances the cytotoxicity of RTX and reverses growth inhibition. Exposure to 20 mM Leucovorin in 11 human colon cancer cell lines results in increased cytotoxicity. The augmentation of Leucovorin slows the reduction of folate levels in tissues, thus enhancing the inhibitory effect of thymidylate synthase on murine colonic tumors. |
| Synonyms | Leucovorin calcium salt pentahydrate, Leucovorin Calcium Pentahydrate |
| Molecular Weight | 601.58 |
| Formula | C20H21CaN7O7·5H2O |
| Cas No. | 6035-45-6 |
| Smiles | O.O.O.O.O.[Ca++].Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC([O-])=O)C([O-])=O)N(C=O)c2c(=O)[nH]1 |
| Relative Density. | no data available |
| Storage | keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | H2O: 10 mM, Sonication is recommended. DMSO: Insoluble | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
H2O
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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