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Verubecestat

🥰Excellent
Catalog No. T7011Cas No. 1286770-55-5
Alias MK-8931

Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.

Verubecestat
Other Forms of Verubecestat:

Verubecestat

🥰Excellent
Purity: 99.55%
Catalog No. T7011Alias MK-8931Cas No. 1286770-55-5
Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$34In StockIn Stock
5 mg$55In StockIn Stock
10 mg$80In StockIn Stock
25 mg$155In StockIn Stock
50 mg$228In StockIn Stock
100 mg$372In StockIn Stock
500 mg$869-In Stock
1 mL x 10 mM (in DMSO)$61In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.55%
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Product Introduction

Bioactivity
Description
Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.
Targets&IC50
BACE1:1.75 nM(Ki), BACE2:0.37 nM(Ki)
In vitro
Verubecestat(MK-8931) effectively reduces Aβ40 in cells with a Ki of 7.8 nM and an IC50 of 13 nM[2].
In vivo
Verubecestat(MK-8931) dramatically lowers CSF and cortex Aβ40 in both rats and cynomolgus monkeys following a single oral dose. Due to the 20 h half-life of MK-8931 it is ideal for once-a-day dosing[2].
SynonymsMK-8931
Chemical Properties
Molecular Weight409.41
FormulaC17H17F2N5O3S
Cas No.1286770-55-5
SmilesCN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Relative Density.1.52±0.1 g/cm3 (Calc.)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 5 mg/mL (12.21 mM), Sonication is recommended.
DMSO: 81 mg/mL (197.85 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.06 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.4425 mL12.2127 mL24.4254 mL122.1270 mL
5 mM0.4885 mL2.4425 mL4.8851 mL24.4254 mL
10 mM0.2443 mL1.2213 mL2.4425 mL12.2127 mL
DMSO
1mg5mg10mg50mg
20 mM0.1221 mL0.6106 mL1.2213 mL6.1063 mL
50 mM0.0489 mL0.2443 mL0.4885 mL2.4425 mL
100 mM0.0244 mL0.1221 mL0.2443 mL1.2213 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

β-SecretaseβSecretaseVerubecestatorallyMK8931MK 8931InhibitorinhibitDiseaseb-SecretasebSecretaseBeta-secretaseBetaSecretaseBACE2BACE1BACEAβ40Alzheimer's
Related Tags: buy Verubecestat | purchase Verubecestat | Verubecestat cost | order Verubecestat | Verubecestat chemical structure | Verubecestat in vivo | Verubecestat in vitro | Verubecestat formula | Verubecestat molecular weight
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