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Anti-EZH2 Antibody (2I680)
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Catalog No. TMAH-00408
Alias Lysine N-methyltransferase 6, KMT6, Histone-lysine N-methyltransferase EZH2, EZH 2, ENX-1, Enhancer of zeste homolog 2, EC 2.1.1.43
Anti-EZH2 Antibody (2I680) is an antibody targeting EZH2. Anti-EZH2 Antibody (2I680) can be used in ELISA, IHC.
Anti-EZH2 Antibody (2I680)
Anti-EZH2 Antibody (2I680)
😃Good
Catalog No. TMAH-00408Alias Lysine N-methyltransferase 6, KMT6, Histone-lysine N-methyltransferase EZH2, EZH 2, ENX-1, Enhancer of zeste homolog 2, EC 2.1.1.43
Anti-EZH2 Antibody (2I680) is an antibody targeting EZH2. Anti-EZH2 Antibody (2I680) can be used in ELISA, IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $208 | 7-10 days | |
| 100 μL | $348 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Monoclonal Application: ELISA, IHC Reactivity: Human |
| Alias | Lysine N-methyltransferase 6, KMT6, Histone-lysine N-methyltransferase EZH2, EZH 2, ENX-1, Enhancer of zeste homolog 2, EC 2.1.1.43 |
| Ig Type | Rabbit IgG |
| Clone | 2I680 |
| Reactivity | Human |
| Verified Activity | IHC image of TMAH-00408 diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| Application | ELISA, IHC |
| Recommended Dose | IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Nucleus. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human KMT6 / EZH2 |
| Antigen Species | Human |
| Gene ID | 2146 |
| Uniprot ID | |
| Biology Area | Epigenetics and Nuclear Signaling, Cancer |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Sci Citations
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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