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Ruzotolimod

Name: Ruzotolimod
Brand: TargetMol
SKU: T61260
Rating: 4.5 (1 reviews)

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Catalog No. T61260Cas No. 1948241-60-8

Alias RO7020531, RO 7020531, RG7854, RG 7854

Ruzotolimod (RO7020531) is an orally active Toll-like receptor 7 agonist that suppresses WHV replication and, in combination with RO-7049389, significantly reduces AAV-HBV viral load, while also serving as an experimental immunomodulatory agent for studying antiviral innate immune responses and therapeutic strategies relevant to SARS-CoV-2 and COVID-19 infection models.

Ruzotolimod

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Catalog No. T61260Alias RO7020531, RO 7020531, RG7854, RG 7854Cas No. 1948241-60-8

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	6-8 weeks	6-8 weeks
50 mg	$1,980	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Ruzotolimod (RO7020531) is an orally active Toll-like receptor 7 agonist that suppresses WHV replication and, in combination with RO-7049389, significantly reduces AAV-HBV viral load, while also serving as an experimental immunomodulatory agent for studying antiviral innate immune responses and therapeutic strategies relevant to SARS-CoV-2 and COVID-19 infection models.
In vivo	In animal models of hepatitis B, Ruzotolimod exhibits antiviral activity and the potential for seroconversion. In AAV-HBV transduced mice, oral administration of Ruzotolimod (100 mg/kg, every 2 days) in combination with RO-7049389 results in sustained suppression of the viral load and a reduction of Hepatitis B surface antigen (HBsAg) levels. In the woodchuck model chronically infected with Woodchuck Hepatitis Virus (WHV), treatment with Ruzotolimod (30-120 mg/kg, p.o., every other day) as monotherapy or in combination with Entecavir leads to the suppression of viral replication. These studies observed the loss of viral antigens and the appearance of anti-surface antibodies (seroconversion), representing a sustained antiviral response after treatment cessation [3][4].
Synonyms	RO7020531, RO 7020531, RG7854, RG 7854

Chemical Properties

Molecular Weight	354.38
Formula	C₁₄H₁₈N₄O₅S
Cas No.	1948241-60-8
Smiles	O=C1N(C=2C(S1)=CN=C(N)N2)[C@@H]3O[C@]([C@@H](OC(C)=O)CC)(C[C@H]3O)[H]

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (282.18 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8218 mL	14.1091 mL	28.2183 mL	141.0915 mL
5 mM	0.5644 mL	2.8218 mL	5.6437 mL	28.2183 mL
10 mM	0.2822 mL	1.4109 mL	2.8218 mL	14.1091 mL
20 mM	0.1411 mL	0.7055 mL	1.4109 mL	7.0546 mL
50 mM	0.0564 mL	0.2822 mL	0.5644 mL	2.8218 mL
100 mM	0.0282 mL	0.1411 mL	0.2822 mL	1.4109 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Ruzotolimod

Ruzotolimod

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In Vivo Formulation Calculator (Clear solution)

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