Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 158.00 | |
5 mg | In stock | $ 397.00 | |
10 mg | In stock | $ 589.00 | |
25 mg | In stock | $ 945.00 | |
50 mg | In stock | $ 1,280.00 | |
100 mg | In stock | $ 1,730.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 458.00 |
Description | GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes. |
In vitro | GNF2133 has an IC50 of >50 µM for GSK3β. GNF2133 significantly improves glucose disposal capacity and increases insulin secretion[1]. |
In vivo | In Diphtheria toxin A (RIP-DTA) mice, GNF2133 (3, 10, 30 mg/kg) significantly improves glucose disposal capacity and increased insulin secretion. In CD-1 mice, GNF2133 (30 mg/kg; p.o.) shows moderate plasma exposure and good oral absorption with oral bioavailability of 22.3%[1]. In Wistar Han rat, GNF2133 (30 mg/kg; p.o.) increases in cell proliferation marker Ki67 and insulin and reduces cyclin D1 levels and overall cell density[1]. |
Molecular Weight | 434.53 |
Formula | C24H30N6O2 |
CAS No. | 2561414-56-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.5 mg/mL (10.36 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
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GNF2133 2561414-56-8 Cell Cycle/Checkpoint Tyrosine Kinase/Adaptors DYRK β-cell RIP-DTA mice Inhibitor insulin secretion inhibit Dual specificity tyrosine regulated kinase glucose disposal Dual specificity tyrosine phosphorylation regulated kinase GNF-2133 CD-1 mice GNF 2133 orally active inhibitor