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Anti-ROS1 Antibody (7L404)
Catalog No. TMAB-12346 Copy Product Info
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Anti-ROS1 Antibody (7L404) is a Mouse antibody targeting ROS1. Anti-ROS1 Antibody (7L404) can be used in WB,IHC-P,IHC-Fr,IF.
Anti-ROS1 Antibody (7L404)
Copy Product Info🥰Excellent
Catalog No. TMAB-12346
Anti-ROS1 Antibody (7L404) is a Mouse antibody targeting ROS1. Anti-ROS1 Antibody (7L404) can be used in WB,IHC-P,IHC-Fr,IF.
Anti-ROS1 Antibody
(7L404)
(7L404)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-ROS1 Antibody (7L404) is a Mouse antibody targeting ROS1. Anti-ROS1 Antibody (7L404) can be used in WB,IHC-P,IHC-Fr,IF. |
| Ig Type | IgG1, k |
| Clone | 7L404 |
| Reactivity | Human |
| Verified Activity | Sample: Lane 1: Recombinant ROS1 protein Primary: Anti-ROS1 (TMAB-12346) at 1/4000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 258 kD Observed band size: 30 kD |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:200-300; IF: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Expressed in brain. Expression is increased in primary gliomas. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008] |
| Immunogen | Recombinant Protein: human ROS1 |
| Antigen Species | Human |
| Gene Name | ROS1 |
| Gene ID | |
| Protein Name | Proto-oncogene tyrosine-protein kinase ROS |
| Uniprot ID | |
| Function | Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. |
| Molecular Weight | Theoretical: 258 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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