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Anti-ROS1 Antibody (7L404)

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Catalog No. TMAB-12346

Anti-ROS1 Antibody (7L404) is a Mouse antibody targeting ROS1. Anti-ROS1 Antibody (7L404) can be used in WB,IHC-P,IHC-Fr,IF.

Anti-ROS1 Antibody (7L404)

Anti-ROS1 Antibody (7L404)

😃Good
Catalog No. TMAB-12346
Anti-ROS1 Antibody (7L404) is a Mouse antibody targeting ROS1. Anti-ROS1 Antibody (7L404) can be used in WB,IHC-P,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2227-10 days7-10 days
100 μL$3727-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-ROS1 Antibody (7L404) is a Mouse antibody targeting ROS1. Anti-ROS1 Antibody (7L404) can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG1, k
Clone
7L404
Reactivity
Human
Application
WB
IHC-P
IHC-Fr
IF
Recommended Dose
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:200-300; IF: 1:100-500
Antibody Type
Monoclonal
Host SpeciesMouse
Subcellular LocalizationCell membrane; Single-pass type I membrane protein.
Tissue SpecificityExpressed in brain. Expression is increased in primary gliomas.
ConstructionHybridoma Monoclonal Antibody
PurificationProtein G purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThis proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]
Antigen Details
Immunogen
Recombinant Protein: human ROS1
Antigen Species
Human
Gene Name
ROS1
Gene ID
6098
Protein Name
Proto-oncogene tyrosine-protein kinase ROS
Uniprot ID
P08922
Function
Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.
Chemical Properties
Molecular WeightTheoretical: 258 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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