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Propranolol hydrochloride

Name: Propranolol hydrochloride
Brand: TargetMol
SKU: T0812
Rating: 4.5 (1 reviews)

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Catalog No. T0812Cas No. 318-98-9

Alias Propranolol HCl, NCS-91523, ICI-45520, AY-64043

Propranolol hydrochloride is a widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.

Propranolol hydrochloride

😃Good

Purity: 100%

Catalog No. T0812Alias Propranolol HCl, NCS-91523, ICI-45520, AY-64043Cas No. 318-98-9

Pack Size	Price	Availability
25 mg	$32	Backorder
50 mg	$46	Backorder
100 mg	$62	Backorder
200 mg	$75	Backorder
500 mg	$98	Backorder
1 g	$119	Backorder
1 mL x 10 mM (in DMSO)	$50	Backorder

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:100%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Propranolol hydrochloride is a widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
Targets&IC50	β-adrenoceptor:12 nM
In vitro	In cultured endothelial or tumor cells, propranolol has been shown to both reduce cAMP levels and simultaneously activate the mitogen-activated protein kinase (MAPK) pathway downstream of βAR inhibition[2]. It displays high affinity for 5-HT1B receptors (Ki= 17 nM), and milder affinity for 5HT1D receptors (Ki= 10.2 μM)[3].
In vivo	Chronic administration of propranolol increased the beta(1)-adrenoceptors but decreased the beta(2)-adrenoceptors without changing total amount of plasma membrane beta-adrenoceptors[4].
Alias	Propranolol HCl, NCS-91523, ICI-45520, AY-64043

Chemical Properties

Molecular Weight	295.804
Formula	C₁₆H₂₂ClNO₂
Cas No.	318-98-9
Smiles	Cl.CC(C)NCC(O)COc1cccc2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (185.93 mM), Sonication is recommended.

Ethanol: <1 mg/mL

H2O: 6 mg/mL (20.28 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3806 mL	16.9031 mL	33.8062 mL	169.0308 mL
5 mM	0.6761 mL	3.3806 mL	6.7612 mL	33.8062 mL
10 mM	0.3381 mL	1.6903 mL	3.3806 mL	16.9031 mL
20 mM	0.1690 mL	0.8452 mL	1.6903 mL	8.4515 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0676 mL	0.3381 mL	0.6761 mL	3.3806 mL
100 mM	0.0338 mL	0.1690 mL	0.3381 mL	1.6903 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc