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FCPR03

Catalog No. T39341 CAS 1917347-65-9

FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively. FCPR03 has neuroprotective, anti-inflammatory, and antidepressant-like effects.

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FCPR03, CAS 1917347-65-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 97.00
5 mg	In stock	$ 247.00
10 mg	In stock	$ 397.00
25 mg	In stock	$ 663.00
50 mg	In stock	$ 945.00
100 mg	In stock	$ 1,280.00
500 mg	In stock	$ 2,570.00
1 mL * 10 mM (in DMSO)	In stock	$ 272.00

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Purity: 100.00%

Biological Description

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Storage & Solubility Information

Description	FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively. FCPR03 has neuroprotective, anti-inflammatory, and antidepressant-like effects.
Targets&IC50	PDE4D7:47 nM (IC50), PDE4B1:31 nM (IC50), PDE4 catalytic domain:60 nM (IC50)
In vitro	FCPR03 displays at least 2100-fold selectivity over other PDEs (PDE1-3 and PDE5-11). In HT-22 cells, FCPR03 (5, 10, and 20 μM) increases cell viability under the oxygen-glucose deprivation (OGD) induced condition in a dose-dependent manner. FCPR03 (20 μM) increases the levels of phosphorylated AKT, GSK-3β, and β-catenin. FCPR03 (20 μM) protects against OGD-induced cellular apoptosis in both HT-22 cells and cortical neurons. The levels of mitochondrial membrane potential (MMP) and ROS are restored by FCPR03. FCPR03 (10 μM) shows significant protective effects[2].
In vivo	In adult male Sprague-Dawley rats following cerebral ischemia-reperfusion, FCPR03 increases the levels of phosphorylated AKT, GSK3β and β-catenin within the ischemic penumbra. In rats following MCAO, FCPR03 (1.25, 2.5, 5 mg/kg; i.p.) reduces the infarct volume and improves neurobehavioral outcomes[2].

Molecular Weight	299.31
Formula	C15H19F2NO3
CAS No.	1917347-65-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (317.40 mM), Sonication is recommended.

References and Literature

1. Zheng-Qiang Zou, et al. Novel Phosphodiesterase 4 Inhibitor FCPR03 Alleviates Lipopolysaccharide-Induced Neuroinflammation by Regulation of the cAMP/PKA/CREB Signaling Pathway and NF- κ B Inhibition. J Pharmacol Exp Ther. 2017 Jul;362(1):67-77. 2. Bingtian Xu, et al. FCPR03, a Novel Phosphodiesterase 4 Inhibitor, Alleviates Cerebral ischemia/reperfusion Injury Through Activation of the AKT/GSK3β/ β-catenin Signaling Pathway. Biochem Pharmacol. 2019 May;163:234-249.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Metabolism Compound Library Bioactive Compounds Library Max Antidepressant Compound Library Immunology/Inflammation Compound Library

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uk-50001 GSK256066 Trifluoroacetate Ziritaxestat OR-1896 Dipyridamole Pimobendan PDE4B-IN-2 CRT0273750

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Keywords

FCPR03 1917347-65-9 Metabolism PDE antidepressant-like PDE4B1 PDE4D7 FCPR-03 PDE4 neuroprotective ischemic AKT GSK3β FCPR 03 inhibit anti-inflammatory Phosphodiesterase (PDE) β-catenin Inhibitor stroke inhibitor

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