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PARP1-IN-5 dihydrochloride

Name: PARP1-IN-5 dihydrochloride
Brand: TargetMol
SKU: T9610
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9610Cas No. 2823308-89-8

PARP1-IN-5 dihydrochloride is an orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer.

PARP1-IN-5 dihydrochloride

🥰Excellent

Purity: 98.01%

Catalog No. T9610Cas No. 2823308-89-8

PARP1-IN-5 dihydrochloride is an orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$84	-	In Stock
5 mg	$198	-	In Stock
10 mg	$313	-	In Stock
25 mg	$622	-	In Stock
50 mg	$872	-	In Stock
1 mL x 10 mM (in DMSO)	$243	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.01%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	PARP1-IN-5 dihydrochloride is an orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer.
Targets&IC50	PARP1:14.7 nM, PARP2:0.9 μM
In vitro	PARP1-IN-5 dihydrochloride (0.1~320 μM) significantly enhances CBP cytotoxicity on A549 cells in a dose-dependent manner but has minimal cytotoxic effects on A549 cells alone. It also decreases MCM2-7 expression and PAR levels in SK-OV-3 cells and increases γ-H2AX expression, exhibiting antitumor effects via PARP-1[1].
In vivo	PARP1-IN-5 dihydrochloride (1000 mg/kg; p.o.) shows no significant difference in body weight and blood routine. PARP1-IN-5 dihydrochloride (25 and 50 mg/kg; p.o.; 12 days) significantly enhances the inhibitory effect of carboplatin on A549 cells at 50 mg/kg. PARP1-IN-5 dihydrochloride (50 mg/kg; p.o.) positively correlates with the expression of PARP-1. PARP1-IN-5 dihydrochloride decreases the expression of PAR and upregulates the expression of γ-H2AX [1].

Chemical Properties

Molecular Weight	537.46
Formula	C₂₅H₂₆Cl₂N₂O₅S
Cas No.	2823308-89-8
Smiles	O=C1C=C(C2=CC=C(O)C=C2)OC3=C(CN4CCN(CC5=CC=CS5)CC4)C(O)=CC(O)=C31.Cl[H].Cl[H]

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (232.58 mM), Sonication is recommended.

H2O: 1 mg/mL (1.86 mM), Sonication and heating to 60℃ are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.44 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8606 mL	9.3030 mL	18.6060 mL	93.0302 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.3721 mL	1.8606 mL	3.7212 mL	18.6060 mL
10 mM	0.1861 mL	0.9303 mL	1.8606 mL	9.3030 mL
20 mM	0.0930 mL	0.4652 mL	0.9303 mL	4.6515 mL
50 mM	0.0372 mL	0.1861 mL	0.3721 mL	1.8606 mL
100 mM	0.0186 mL	0.0930 mL	0.1861 mL	0.9303 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc