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PARP1-IN-5 dihydrochloride

Name: PARP1-IN-5 dihydrochloride
Brand: TargetMol
SKU: T9610
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9610Cas No. 2823308-89-8

PARP1-IN-5 dihydrochloride is an orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer.

PARP1-IN-5 dihydrochloride

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Purity: 98.01%

Catalog No. T9610Cas No. 2823308-89-8

PARP1-IN-5 dihydrochloride is an orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$84	-	In Stock
5 mg	$198	-	In Stock
10 mg	$313	-	In Stock
25 mg	$622	-	In Stock
50 mg	$872	-	In Stock
1 mL x 10 mM (in DMSO)	$243	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.01%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	PARP1-IN-5 dihydrochloride is an orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer.
Targets&IC50	PARP2:0.9 μM, PARP1:14.7 nM
In vitro	PARP1-IN-5 dihydrochloride (0.1~320 μM) significantly enhances CBP cytotoxicity on A549 cells in a dose-dependent manner but has minimal cytotoxic effects on A549 cells alone. It also decreases MCM2-7 expression and PAR levels in SK-OV-3 cells and increases γ-H2AX expression, exhibiting antitumor effects via PARP-1[1].
In vivo	PARP1-IN-5 dihydrochloride (1000 mg/kg; p.o.) shows no significant difference in body weight and blood routine. PARP1-IN-5 dihydrochloride (25 and 50 mg/kg; p.o.; 12 days) significantly enhances the inhibitory effect of carboplatin on A549 cells at 50 mg/kg. PARP1-IN-5 dihydrochloride (50 mg/kg; p.o.) positively correlates with the expression of PARP-1. PARP1-IN-5 dihydrochloride decreases the expression of PAR and upregulates the expression of γ-H2AX [1].

Chemical Properties

Molecular Weight	537.46
Formula	C₂₅H₂₆Cl₂N₂O₅S
Cas No.	2823308-89-8
Smiles	O=C1C=C(C2=CC=C(O)C=C2)OC3=C(CN4CCN(CC5=CC=CS5)CC4)C(O)=CC(O)=C31.Cl[H].Cl[H]

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (232.58 mM), Sonication is recommended.

H2O: 1 mg/mL (1.86 mM), Sonication and heating to 60℃ are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.44 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8606 mL	9.3030 mL	18.6060 mL	93.0302 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.3721 mL	1.8606 mL	3.7212 mL	18.6060 mL
10 mM	0.1861 mL	0.9303 mL	1.8606 mL	9.3030 mL
20 mM	0.0930 mL	0.4652 mL	0.9303 mL	4.6515 mL
50 mM	0.0372 mL	0.1861 mL	0.3721 mL	1.8606 mL
100 mM	0.0186 mL	0.0930 mL	0.1861 mL	0.9303 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc