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TAT-MEK1

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Catalog No. TP2632Cas No. 566872-16-0

TAT-MEK1, an inhibitor of ERK2, comprises TAT and MEK1 (N-terminal). The TAT component (YGRKKRRQRRR) is a cell-penetrating peptide derived from the human immunodeficiency (HIV-1) transcriptional trans activator (TAT). TAT-MEK1 has an IC50 of 29 μM for ERK2 in vitro [1] [2].

TAT-MEK1

TAT-MEK1

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Catalog No. TP2632Cas No. 566872-16-0
TAT-MEK1, an inhibitor of ERK2, comprises TAT and MEK1 (N-terminal). The TAT component (YGRKKRRQRRR) is a cell-penetrating peptide derived from the human immunodeficiency (HIV-1) transcriptional trans activator (TAT). TAT-MEK1 has an IC50 of 29 μM for ERK2 in vitro [1] [2].
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Product Introduction

Bioactivity
Description
TAT-MEK1, an inhibitor of ERK2, comprises TAT and MEK1 (N-terminal). The TAT component (YGRKKRRQRRR) is a cell-penetrating peptide derived from the human immunodeficiency (HIV-1) transcriptional trans activator (TAT). TAT-MEK1 has an IC50 of 29 μM for ERK2 in vitro [1] [2].
In vitro
TAT-MEK1 (100 μM, 30 min) effectively inhibits luciferase activity in NIH 3T3 and PC12 cells and suppresses ERK2 activation [2]. Western Blot Analysis [2] was conducted on cell lines NIH 3T3 and PC12 with a concentration of 100 μM and an incubation time of 30 minutes, resulting in decreased luciferase and ERK2 activities.
Chemical Properties
Molecular Weight3146.77
FormulaC136H241N53O31S
Cas No.566872-16-0
SmilesC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]1N(C([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CC2=CC=C(O)C=C2)NC(CN)=O)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CCCCN)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)CCSC)=O)CCC1)CCCCN)=O)CCCCN)=O)CCCCN)(=O)N3[C@H](C(N[C@H](C(=O)N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N5[C@H](C(N)=O)CCC5)CC(N)=O)=O)CC(C)C)=O)CCC(N)=O)=O)[C@H](CC)C)=O)CCC4)[C@@H](C)O)=O)CCC3
SequenceGly-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro-NH2
Sequence ShortGYGRKKRRQRRRGMPKKKPTPIQLNP
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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