Anti-Phospho-ITGB3 (Tyr785) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ITGB3 (Tyr785). Anti-Phospho-ITGB3 (Tyr785) Polyclonal Antibody can be used in WB.

IgG

Human (predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep)

Sample:
Lane 1: Human U87MG cell lysates
Lane 2: Human DU145 cell lysates
Primary: Anti-phospho-ITGB3 (Tyr785) (TMAB-10888) at 1/200 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 87 kDa
Observed band size: 87 kDa

WB: 1:500-2000

Polyclonal

KLH conjugated Synthesised phosphopeptide: human ITGB3 around the phosphorylation site of Tyr785

Human

ITGB3

Integrin beta-3

Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.