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VU6015929

Name: VU6015929
Brand: TargetMol
SKU: T7862
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7862Cas No. 2442597-56-8

VU6015929 is an inhibitor of active dual discoidin domain receptor 1/2 (DDR1/2)( IC50s of 4.67 nM and 7.39 nM, respectively).

VU6015929

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Purity: 99.96%

Catalog No. T7862Cas No. 2442597-56-8

VU6015929 is an inhibitor of active dual discoidin domain receptor 1/2 (DDR1/2)( IC50s of 4.67 nM and 7.39 nM, respectively).

Pack Size	Price	Availability
1 mg	$64	In Stock
5 mg	$143	In Stock
10 mg	$223	In Stock
25 mg	$369	In Stock
50 mg	$521	In Stock
100 mg	$702	In Stock
200 mg	$946	In Stock
1 mL x 10 mM (in DMSO)	$153	In Stock

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Purity:99.96%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	VU6015929 is an inhibitor of active dual discoidin domain receptor 1/2 (DDR1/2)( IC50s of 4.67 nM and 7.39 nM, respectively).
Targets&IC50	DDR1:4.67 nM , DDR2:7.39 nM
In vitro	VU6015929 potently blocks collagen-induced DDR1 activation and collagen-IV production, suggesting DDR1 inhibition as an exciting target for antifibrotic therapy[1].

Chemical Properties

Molecular Weight	485.43
Formula	C₂₄H₁₉F₄N₅O₂
Cas No.	2442597-56-8
Smiles	Cn1ccc(n1)-c1cncc(CNc2cc(ccc2F)C(=O)Nc2cccc(OC(F)(F)F)c2)c1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (515.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0600 mL	10.3001 mL	20.6003 mL	103.0015 mL
5 mM	0.4120 mL	2.0600 mL	4.1201 mL	20.6003 mL
10 mM	0.2060 mL	1.0300 mL	2.0600 mL	10.3001 mL
20 mM	0.1030 mL	0.5150 mL	1.0300 mL	5.1501 mL
50 mM	0.0412 mL	0.2060 mL	0.4120 mL	2.0600 mL
100 mM	0.0206 mL	0.1030 mL	0.2060 mL	1.0300 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc