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Sodium dichloroacetate

Name: Sodium dichloroacetate
Brand: TargetMol
SKU: T3604
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3604Cas No. 2156-56-1

Alias Sodium Dichloroacetate, Sodium dichloroacetate (DCA), Sodium bichloroacetic acid, DCA sodium salt

Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion channel axis, trigger apoptosis in cancer cells, and inhibit tumor growth.

Sodium dichloroacetate

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Purity: 99.87%

Catalog No. T3604Alias Sodium Dichloroacetate, Sodium dichloroacetate (DCA), Sodium bichloroacetic acid, DCA sodium saltCas No. 2156-56-1

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$31	In Stock	In Stock
100 mg	$45	In Stock	In Stock
500 mg	$92	-	In Stock
1 g	$133	-	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.87%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Sodium dichloroacetate AI Summary

Sodium dichloroacetate exhibits inhibitory activity against Pyruvate Dehydrogenase Kinase (PDHK) with an IC50 greater than 1,000,000 nM. It increases the oxidation of lactate in human skin fibroblasts at an EC50 of 130,000 nM. In vivo studies on Sprague-Dawley rats show a 70% reduction in lactate levels after 2 hours at a dose of 1 µmol/kg. The compound also demonstrates anticancer activity in various human cancer cell lines (BGC823, KB, A549, Bel7402, MCF7, HCT116) with IC50 values in the micromolar to nanomolar range. Additionally, it shows cytotoxicity against non-cancerous cells such as human L02 cells and affects mitochondrial function in human MCF7 cells by inducing mitochondrial membrane potential collapse and increasing ROS generation. Sodium dichloroacetate has potential inhibitory effects on Polymerase Kappa with a potency of 23,778 nM. Furthermore, it exhibits anti-hypersensitive activity in a pulmonary arterial hypertension rat model by reducing pulmonary and cardiac morphological changes at a dose of 15.5 mg/kg orally for 14 days..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion channel axis, trigger apoptosis in cancer cells, and inhibit tumor growth.
Targets&IC50	PC3 cells:15.7 mM, NCI-H4 cells:3892 μM, KB cells:1424 μM, SH-SY5Y cells:17.4 mM, A375 cells:20.1 mM, 4T1 cells:> 100 μM, MCF-7 cells:12.35 mM, L02 cells:21.7 mM, PDK2:183 μM, Bel-7402 cells:860 μM, HCT116 cells:9.8 mM, NCI-H1650 cells:16.3 mM, PDK4:80 μM, A549 cells:20.1 mM, BGC-823 cells:1051 μM
In vitro	METHODS: Tumor cells A549, MO59K and MCF-7 and normal cells SAEC were treated with Sodium dichloroacetate (0.5 mM) for 48 h. Mitochondrial membrane potential ΔΨm was detected using fluorescent dye. RESULTS: Incubation of all three types of tumor cells with Sodium dichloroacetate reversed hyperpolarization and restored ΔΨm to the level of normal cells. In contrast, Sodium dichloroacetate did not alter ΔΨm in SAEC. [1] METHODS: OSCC cell lines HSC-2, HSC-3 and PE15 were treated with Sodium dichloroacetate (1-10 mM) for 24 h. Cell viability was measured using the MST assay. RESULTS: HSC-2 and HSC-3 showed more significant unique sensitivity to the drugs. Compared with HEK 293, the viability of both HSC-2 and HSC-3 was about 30% at 10 mM Sodium dichloroacetate, while the viability of PE15 was 75-80%. [2]
In vivo	METHODS: To study the effect on energy expenditure in ApoE-/- mice, Sodium dichloroacetate (100-150 mg/kg) was administered by gavage once daily for four weeks to ApoE-/- mice fed the western diet model of atherosclerosis. RESULTS: Western diet-fed ApoE-/- mice developed atherosclerotic plaques and hyperlipidemia, as well as obesity, which were significantly ameliorated by the administration of Sodium dichloroacetate. Enhanced glucose oxidation by Sodium dichloroacetate protects against atherosclerosis by inducing hepatic FGF21 expression and BAT activation, thereby increasing the risk of atherosclerosis. atherosclerosis, thereby increasing energy expenditure for calorie production. [3]
Synonyms	Sodium Dichloroacetate, Sodium dichloroacetate (DCA), Sodium bichloroacetic acid, DCA sodium salt

Chemical Properties

Molecular Weight	150.92
Formula	C₂HCl₂NaO₂
Cas No.	2156-56-1
Smiles	C(C(=O)[O-])(Cl)Cl.[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 166.66 mg/mL (1104.29 mM), Sonication is recommended.

DMSO: 26 mg/mL (172.28 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	6.6260 mL	33.1301 mL	66.2603 mL	331.3014 mL
5 mM	1.3252 mL	6.6260 mL	13.2521 mL	66.2603 mL
10 mM	0.6626 mL	3.3130 mL	6.6260 mL	33.1301 mL
20 mM	0.3313 mL	1.6565 mL	3.3130 mL	16.5651 mL
50 mM	0.1325 mL	0.6626 mL	1.3252 mL	6.6260 mL
100 mM	0.0663 mL	0.3313 mL	0.6626 mL	3.3130 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc