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SMCC

Catalog No. T9116Cas No. 64987-85-5
Alias N-Succinimidyl 4-(N-maleimidomethyl)cycl

SMCC (N-Succinimidyl 4-(N-maleimidomethyl)cycl) is a heterobifunctional protein crosslinker.

SMCC

SMCC

Purity: 98.96%
Catalog No. T9116Alias N-Succinimidyl 4-(N-maleimidomethyl)cyclCas No. 64987-85-5
SMCC (N-Succinimidyl 4-(N-maleimidomethyl)cycl) is a heterobifunctional protein crosslinker.
Pack SizePriceAvailabilityQuantity
50 mg$30In Stock
100 mg$45In Stock
500 mg$85In Stock
1 g$125In Stock
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Purity:98.96%
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Product Introduction

Bioactivity
Description
SMCC (N-Succinimidyl 4-(N-maleimidomethyl)cycl) is a heterobifunctional protein crosslinker.
In vitro
N-Succinimidyl 4-(N-maleimidomethyl)cycl(SMCC) is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length cyclohexane-stabilized spacer arm (8.3 angstroms). SMCC conjugation occurs via a maleimide group that is sulfhydryl (thiol; -SH) reactive and a NHS ester group that is amine reactive and forms stable, covalent protein crosslinks.
Cell Research
Branched PEI (25 kDa) was dissolved in PBS buffer to yield a concentration of 1 mg/mL. No-weigh Sulfo-SMCC was dissolved in Milli-Q water with a concentration of 10 mg/mL, then a certain of the prepared no-weigh SulfoSMCC solution was added into 2 mL PEI solution to incubate for 30 min at 37 C. After the PEI-SMCC polymer was formed, TAT solution was added into the polymer at the given molar ratio and incubated for 2 h at 4 C. The concentration of unreacted SMCC and unreacted TAT were removed using Zeba Spin Desalting Columns. The polymer PEI-SMCC-TAT was also characterized and analyzed through FTIR to check if each element was added to the PEI backbone.
AliasN-Succinimidyl 4-(N-maleimidomethyl)cycl
Chemical Properties
Molecular Weight334.32
FormulaC16H18N2O6
Cas No.64987-85-5
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 25 mg/mL (74.78 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9911 mL14.9557 mL29.9115 mL149.5573 mL
5 mM0.5982 mL2.9911 mL5.9823 mL29.9115 mL
10 mM0.2991 mL1.4956 mL2.9911 mL14.9557 mL
20 mM0.1496 mL0.7478 mL1.4956 mL7.4779 mL
50 mM0.0598 mL0.2991 mL0.5982 mL2.9911 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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