LILRB1/CD85j/ILT2 Protein, Human, Recombinant (His)

LILRB1 (Leukocyte Immunoglobulin Like Receptor B1) is a Protein Coding gene. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). LILRB1 is encoded within the leukocyte receptor complex on 19q13.4, previously implicated to be a susceptibility region to systemic lupus erythematosus (SLE). LILRB1 binds to a wide range of Major Histocompatibility Complex Class I molecules (MHCIs) and transduces negative signals that can, for example, prevent the killing of MHCI-expressing cells. LILRB1 transcription is correlated with surface protein expression on NK cells. Diseases associated with LILRB1 include Alzheimer's Disease 12 and Severe Pre-Eclampsia.

Pack Size	Availability	Price/USD
100 μg	In stock	$ 316.00
200 μg	5 days	$ 560.00
500 μg	5 days	$ 1,180.00

Pack Size

Availability

Price/USD

Quantity

100 μg

In stock

$ 316.00

200 μg

5 days

$ 560.00

500 μg

5 days

$ 1,180.00

Biological Information

Testing in progress

Description

Species	Human
Expression System	HEK293
Tag	His
Accession Number	D9IDM8
Synonyms	ILT-2, leukocyte immunoglobulin like receptor B1, CD85j, MIR-7, LIR-1, XXbac-BCX85G21.4, LIR1, ILT2, MIR7
Construction	A DNA sequence encoding the human LILRB1 (ADJ55949.1) (Met1-His458) was expressed with a C-terminal polyhistidine tag.
Protein Purity	≥ 95 % as determined by SDS-PAGE ≥ 95 % as determined by SEC-HPLC.
Molecular Weight	Approxiamtely 48.6 kDa

Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method.
Formulation	Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution	A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage	Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	LILRB1 (Leukocyte Immunoglobulin Like Receptor B1) is a Protein Coding gene. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). LILRB1 is encoded within the leukocyte receptor complex on 19q13.4, previously implicated to be a susceptibility region to systemic lupus erythematosus (SLE). LILRB1 binds to a wide range of Major Histocompatibility Complex Class I molecules (MHCIs) and transduces negative signals that can, for example, prevent the killing of MHCI-expressing cells. LILRB1 transcription is correlated with surface protein expression on NK cells. Diseases associated with LILRB1 include Alzheimer's Disease 12 and Severe Pre-Eclampsia.

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LILRB1/CD85j/ILT2 Protein, Human, Recombinant (His)

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